eng
Shiraz University of Medical Sciences
Journal of Dentistry
2345-6485
2345-6418
2016-09-01
17
3
164
170
41702
Original Article
Efficacy of Transcutaneous Electric Nerve Stimulation on Parotid Saliva Flow Rate in Relation to Age and Gender
Manu Dhillon
drmanudhillon@gmail.com
1
Srinivasa M Raju
2
Raviprakash S Mohan
3
Divya Tomar
4
Dept. of Oral Medicine and Radiology, ITS Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India.
Dept. of Oral Medicine and Radiology, Rama Dental College, Kanpur, Uttar Pradesh, India.
Dept. of Oral Medicine and Radiology, Subharti Dental College, Meerut, Uttar Pradesh, India.
Dept. of Pedodontics and Preventive Dentistry, SBB Dental College, Ghaziabad, Uttar Pradesh, India.
Statement of the Problem: Treatment with salivary substitutes and stimulation of salivary flow by either mechanical or pharmacologic methods has side effects and only provides symptomatic relief but no long-lasting results.Purpose: To assess the effectiveness of extraoral transcutaneous electric nerve stimulation (TENS) as a mean of stimulating salivary function in healthy adult subjects; as well as to determine the gender and age-dependent changes in salivary flow rates of unstimulated and stimulated parotid saliva.Materials and Method: Hundred patients were divided into two groups; Group I aged 20-40 and Group II aged ≥ 60 years. The TENS electrode pads were externally placed on the skin overlying the parotid glands. Unstimulated and stimulated parotid saliva was collected for 5 minutes each by using standardized collection techniques.Results: Eighty seven of 100 subjects demonstrated increased salivary flow when stimulated via the TENS unit. Ten experienced no increase and 3 experienced a decrease. The mean unstimulated salivary flow rate was 0.01872 ml/min in Group I and 0.0088 ml/min in Group II. The mean stimulated salivary flow rate was 0.03084 ml/min (SD= 0.01248) in Group I, and 0.01556 ml/min (SD 0.0101) in Group II. After stimulation, the amount of salivary flow increased significantly in both groups (p< 0.001). Statistical comparison of the two groups revealed them to be significantly different (p< 0.001), with Group I producing more saliva. Gender-wise, no statistically significant difference was seen among the subjects in Group I (p = 0.148), and those in Group II (p= 0.448). Out of 12 subjects with 0 baseline flows, 7 continued to have no flow. Five subjects observed side effects, although minimal and transient.Conclusion: The TENS unit was effective in increasing parotid gland salivary flow in healthy subjects. There was age-related but no gender-related variability in parotid salivary flow rate.
https://dentjods.sums.ac.ir/article_41702_e066fa1665cdb29b32c52e20a6941daa.pdf
eng
Shiraz University of Medical Sciences
Journal of Dentistry
2345-6485
2345-6418
2016-09-01
17
3
171
176
41704
Original Article
The Effect of Nonsurgical Periodontal Therapy on Trichomonas Tenax and Entamoeba Gingivalis in Patients with Chronic Periodontitis
Fahimeh Rashidi Maybodi
f_rashidi63@yahoo.com
1
Ahmad Haerian Ardakani
2
Ali Fattahi Bafghi
afbafghi@ssu.ac.ir
3
Alireza Haerian Ardakani
haerian.alireza@gmail.com
4
Akram Zafarbakhsh
zafarbakhsh.akram@gmail.com
5
Dept. of Periodontology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Dept. of Periodontology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Dept. of Parasitology & Mycology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Dept. of Orthodontics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Dept. of Periodontology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Statement of the Problem: Trichomonas tenax and Entamoeba gingivalis are commensal protozoa which inhabit the human oral cavity. These parasites are found in patients with poor oral hygiene and might be a reason for progressive periodontal diseases.Purpose: The aim of this study was to evaluate the effect of nonsurgical periodontal treatment on the frequency of these protozoa in saliva and plaque samples.Materials and Method: In this clinical trial, samples of saliva and dental plaque were collected from 46 patients with moderate to severe chronic periodontitis before and after periodontal therapy. The samples were assessed for the frequency of parasites.Results: The frequency of Entamoeba gingivalis was reduced in saliva (p= 0.007) and plaque (p= 0.027) three weeks after the treatment. Likewise, the frequency of Trichomonas tenax reduced in saliva (p= 0.030); however, the decrease was not significant in plaque (p= 0.913). Trichomonas tenax frequency in dental plaque directly related to the severity of periodontitis (r= 0.565, p≤ 0.000). In contrast, the number of Entamoeba gingivalis in both saliva (r= -0.405, p≤ 0.005) and plaque (r= -0.304, p= 0.040) was inversely related with the severity of the periodontal disease.Conclusion: Nonsurgical periodontal treatment could reduce the number of Trichomonas Tenax and Entamoeba gingivalis in the oral environment of patients with chronic periodontitis.
https://dentjods.sums.ac.ir/article_41704_59a58df3d00398c84bb3c4a48e9b2509.pdf
eng
Shiraz University of Medical Sciences
Journal of Dentistry
2345-6485
2345-6418
2016-09-01
17
3
177
184
41706
Original Article
Comparison between Computed Tomography and Ultrasonography in Detecting Foreign Bodies Regarding Their Composition and Depth: An In Vitro Study
Abdolaziz Haghnegahdar
shark_h_teh@yahoo.com
1
Alireza Shakibafard
shakibafarda@yahoo.com
2
Negar Khosravifard
ngrkhosravi@yahoo.com
3
Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Specialist in Radiology and Sonography, TABA Medical Imaging Center, Shiraz, Iran.
Postgraduate Student in Oral and Maxillofacial Radiology, Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Statement of the Problem: Impaction of foreign bodies in the soft tissues is a sequela of traumatic and penetrating injuries. Such foreign bodies should be removed due to the complications they cause. Patient’s history, clinical evaluation and imaging examinations aid in the proper detection and localization of the foreign bodies. Purpose: The aim of the present study was to compare the sensitivity of computed tomography (CT) and ultrasonography for detecting foreign bodies in in-vitro models simulating facial soft tissues.Materials and Method: Fifty foreign particles with five different compositions including wood, glass, metal, plastic, and stone were embedded in five calf tongues at 1, 2, 3, 4 and 5 cm depths. CT and ultrasonography were compared regarding their capability of detecting and localizing the foreign bodies.Results: Wood and plastic foreign bodies were demonstrated more clearly on ultrasonography images. High density materials such as metal, stone, and glass were detected with almost the same accuracy on CT and ultrasonography examinations. Visibility of the foreign bodies deteriorated on ultrasonography images as their depth increased; however, CT appearances of the foreign particles were not influenced by their depths.Conclusion: Ultrasonography is an appropriate technique for detection of foreign bodies especially the ones with low density. Therefore, it seems logical to perform ultrasonography in combination with CT in cases with the suspicion of foreign body impaction.
https://dentjods.sums.ac.ir/article_41706_cc6682eb0744cc7e8edebaa5f685ea52.pdf
eng
Shiraz University of Medical Sciences
Journal of Dentistry
2345-6485
2345-6418
2016-09-01
17
3
185
192
41707
Original Article
Evaluation of the Effect of Two Different Systemic Doses of Viola Odorata on Prevention of Induced Tongue Dysplasia in Rats
Sanaz Helli
dr.helli@gmail.com
1
Hossein Damghani
sunnuday_zz@yahoo.com
2
Daryoush Mohajeri
daryoushmohajeri@yahoo.com
3
Mehran Mesgari Abbasi
mesgarim@tbzmed.ac.ir
4
Rana Attaran
ranaattaran@yahoo.com
5
Maryam Zahed
maryamzhd@yahoo.com
6
Oral Medicine Specialist, Tabriz University of Medical Sciences, Tabriz, Iran.
Post-graduate Student, Dept. of Oral Pathology, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Dept. of Pathobiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz Iran.
Dept. of Oral and Maxillofacial Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Dept. of Oral and Maxillofacial Medicine, Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Statement of the Problem: Oral cancer is among the ten most common cancers worldwide. It affects the life quality of patients in many ways.Purpose: The aim of this study was to compare the effects of two different systemic doses of Viola Odorata syrup on the prevention of 4-Nitroquinoline-1-oxide (4-NQO) induced tongue dysplasia in rats.Materials and Method: Forty-eight male Wistar rats were divided into four groups of A, B, C and D. Group A served as the control group. The rats in groups B to D received 30 ppm of 4-NQO in drinking water for 12 weeks. Additionally, the rats in groups B and C received Viola Odorata syrup at doses of 15 and 5 ml/kg, respectively, 3 times a week. Body weights were measured three times a week. At the end, the rats were euthanized and the tongue was removed. Histological evaluations for carcinogenesis were carried out under a light microscope.Results: The mean body weight of the rats in groups B, C, and D were lower than that in group A (p< 0.01). After 12 weeks of treatment, microscopically no histological changes of the tongue base epithelia were observed in the control group. The rats in group B did not show severe dysplastic changes; only mild to moderate histological changes including hyperplasia and hyperkeratosis were evident. These incidences were significantly more apparent in groups C with moderate to severe changes (p< 0.05) and group D with severe dysplastic changes (p< 0.01). Almost all rats in group D had hyperplasia and manifested all of the stages of dysplasia.Conclusion: Viola Odorata extract has dose-dependent inhibitory effects on the development of tongue induced dysplasia.
https://dentjods.sums.ac.ir/article_41707_54a6de0505d86e7a0644f92bad1b087d.pdf
eng
Shiraz University of Medical Sciences
Journal of Dentistry
2345-6485
2345-6418
2016-09-01
17
3
193
200
41708
Original Article
Clinical Comparison of Full and Partial Double Pedicle Flaps with Connective Tissue Grafts for Treatment of Gingival Recession
Ardeshir Ranjbari
ranjbaria@yahoo.com
1
Gholam Ali Gholami
dr_a_gholami@yahoo.com
2
Reza Amid
reza_amid@yahoo.com
3
Mahdi Kadkhodazadeh
kadkhodazadehmahdi@yahoo.com
4
Navid Youssefi
navid.youssefi88@yahoo.com
5
Amir Reza Mehdizadeh
mehdizadeh.cna88@yahoo.com
6
Maryam Aghaloo
7
Periodontist, Private Practitioner, Ahvaz, Iran.
Dept. of Periodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dept. of Periodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dental Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dentist, Dental Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dental Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Periodontist, Private Practitioner, Ahvaz, Iran.
Statement of the Problem: Gingival recession has been considered as the most challenging issue in the field of periodontal plastic surgery. Purpose: The purpose of this study was to evaluate the clinical efficacy of root coverage procedures by using partial thickness double pedicle graft and compare it with full thickness double pedicle graft.Materials and Method: Eight patients, aged 15 to 58 years including 6 females and 2 males with 20 paired (mirror image) defects with class I and II gingival recession were randomly assigned into two groups. Clinical parameters such as recession depth, recession width, clinical attachment level, probing depth, and width of keratinized tissue were measured at the baseline and 6 months post-surgery. A mucosal double papillary flap was elevated and the respective root was thoroughly planed. The connective tissue graft was harvested from the palate, and then adapted over the root. The pedicle flap was secured over the connective tissue graft and sutured. The surgical technique was similar in the control group except for the prepared double pedicle graft which was full thickness.Results: The mean root coverage was 88.14% (2.83 mm) in the test group and 85.7% (2.75 mm) in the control group. No statistical differences were found in the mean reduction of vertical recession, width of recession, or probing depth between the test and control groups. In both procedures, the width of keratinized tissue increased after three months and the difference between the two groups was not statistically significant in this respect.Conclusion: Connective tissue with partial and full thickness double pedicle grafts can be successfully used for treatment of marginal gingival recession.
https://dentjods.sums.ac.ir/article_41708_57f4d19119dd2fa3eccc6a5fbcc3443c.pdf
eng
Shiraz University of Medical Sciences
Journal of Dentistry
2345-6485
2345-6418
2016-09-01
17
3
201
206
41709
Original Article
Evaluation of the Flexural Strength of Interim Restorative Materials in Fixed Prosthodontics
Hanieh Mehrpour
hanieh.mehrpour@yahoo.com
1
Ehsan Farjood
2
Rashin Giti
rashingiti@yahoo.com
3
Alireza Barfi Ghasrdashti
4
Hossein Heidari
5
Biomaterials Research Center, Postgraduate Dept. of Prosthodontic Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Dept. of Prosthodontics, School of Dentistry, Hormozgan University of Medical Sciences, Bandarabbas, Iran.
Biomaterials Research Center, Postgraduate Dept. of Prosthodontic Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Biomaterials Research Center, Postgraduate Dept. of Prosthodontic Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Biomaterials Research Center, Postgraduate Dept. of Prosthodontic Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Statement of the Problem: Mechanical properties of interim restorations are considered as important factors specially when selecting materials for long-term application or for patients with para-functional habits. Flexural strength is one of the most important components of these restorations.Purpose: The purpose of this study was to compare the flexural strength of five interim restorative materials.Materials and Method: Fifty identical samples sized 25×2×2-mm were made from five interim materials (TempSpan; Protemp 4, Unifast III, Trim, and Revotek LC) according to ADA specification #27. The specimens were stored in artificial saliva for 2 weeks and then thermocycled for 2500 cycles (5-55˚C). A standard three-point bending test was conducted on the specimens with a universal testing machine at a crosshead speed of 0.75mm/min. Data were analyzed by using one-way ANOVA and Tamhane’s post-hoc tests to measure the flexural strength of temporary materials.Results: One of the bis-acryl resins (TempSpan) showed the highest, and the light polymerized resin (Revotek LC) showed the lowest flexural strength. The mean values of flexural strength (MPa) for the examined materials were as follow: TempSpan=120.00, Protemp 4=113.00, Unifast III=64.20, Trim= 63.73 and Revotek LC=47.16. There were significant differences between all materials except Trim and Unifast III which did not show any statistical significant difference.Conclusion: Bis-acryl resins were statistically superior to traditional methacrylate and light-cured resins. Therefore, application of bis-acryl resins should be deliberated in patients with heavy occlusion and in cases that need long-term use of interim restorations.
https://dentjods.sums.ac.ir/article_41709_ce43de6f06b8e06fea85028aa2eb21e0.pdf
eng
Shiraz University of Medical Sciences
Journal of Dentistry
2345-6485
2345-6418
2016-09-01
17
3
207
212
41710
Original Article
Outcome of Neoadjuvant Chemotherapy on Local Recurrence and Distant Metastasis of Oral Squamous Cell Carcinoma: A Retrospective Study
Reza Tabrizi
tabmed@gmail.com
1
Ata Garajei
tani_sami1313@yahoo.com
2
Ehsan Shafiee
eshafiee@sums.ac.ir
3
Samira Jamshidi
4
Dept. of Oral and Maxillofacial Surgery and Research Director, Craniomaxillofacial Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Postgraduate Student, Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Dept. of Oral and Maxillofacial Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Postgraduate Student, Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Statement of the Problem: Neoadjuvant chemotherapy (NCH) is controversial in the treatment of oral squamous cell carcinoma (OSCC).Purpose: The aim of this study was to evaluate the efficacy of NCH on OSCC prognosis.Materials and Method: In this retrospective cohort study, 94 patients were studied in two groups. The patients in group 1 received NCH before the surgery, and those in group 2 underwent resection without any chemotherapy prior to surgery. The employed NCH agents consisted of cisplatin in combination with 5-fluorouracil in two treatment courses. Tumor size, lymph node involvement, age, and follow-up time were considered as variable factors of the study. Local recurrence (LR) and distant metastasis (DM) were outcomes of the study.Results: Comparison of LR and DM in various tumor sizes demonstrated no significant difference between the two groups (p> 0.05). Analysis of the data did not show any statistically significant difference between the groups for LR in subjects with N0, N1 and N2. Each one-year increase in age was associated with 10% increase in the hazard ratio (HR) (HR distance metastasis Y/N = 1.10, p= 0.05). In the same analysis, when considering LR as a dependent factor, LR risk in N2 was 3 times more than in N1 (p= 0.02). LR risk in N3 was 5 times more than in N1 [HR local recurrence (p= 0.006).Conclusion: Based on our results, neoadjuvant chemotherapy with combination of cisplatin and 5-fluorouracil may not improve prognosis of OSCC. However, further studies are suggested to assess other neoadjuvant chemotherapy protocols in OSCC patients.
https://dentjods.sums.ac.ir/article_41710_e8dea583445e9c329b4a21b85bb4f736.pdf
eng
Shiraz University of Medical Sciences
Journal of Dentistry
2345-6485
2345-6418
2016-09-01
17
3
213
218
41711
Original Article
Antimicrobial Activity of Peganum Harmala L. on Streptococcus mutans Compared to 0.2% Chlorhexidine
Mohammad Motamedifar
motamedm@sums.ac.ir
1
Hengameh Khosropanah
2
Shima Dabiri
shima_baran2009@yahoo.com
3
Shiraz HIV/AIDS Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Dept. of Periodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Statement of the Problem: Dental caries is one the most prevalent diseases that affects humans throughout their lives. Streptococcus mutans (S. mutans) is recognized as the most important microorganism during tooth cariogenicity. Reducing this germ in oral cavity can reduce the rate of tooth decays in humans.Purpose: The present study compared the antimicrobial activity of ethanolic extract of Peganum harmala L. seeds and 0.2% chlorhexidine on S. mutans.Materials and Method: Agar diffusion technique and micro broth dilution method were employed to test the antimicrobial effects of these two agents on S. mutans. Moreover, the cytotoxicity of ethanolic extract of P. harmala was studied on Vero cells by MTT (thiazolyl blue tetrazolium dye) colorimetric method. The data were analyzed with descriptive methods.Results: Concentrations of 50, 25, and 12.5 mg/mL of the extract made inhibition zones of bacterial growth around the wells; but, lower concentrations could not inhibit the growth of S. mutans. Besides, the antimicrobial effect of 0.2% chlorhexidine was more than 50 mg/mL of the extract. Minimum inhibitory concentration (MIC) of the extract on S. mutans was 1.83±0.6 mg/mL and minimum bactericidal concentration (MBC) was 4.3±1 mg/mL. The MIC and MBC for 0.2% chlorhexidine were reported to be 0.19 mg/mL, and 0.78 mg/mL, respectively. The extract concentrations more than 0.5 mg/mL were toxic and caused more than 50% Vero cell death.Conclusion: Despite the remarkable antimicrobial effects of high concentrations of P. harmala on S. mutans, high cell toxicity of this plant would restrict its in vivo therapeutic use.
https://dentjods.sums.ac.ir/article_41711_93097eaafea948bd249b8b145d402529.pdf
eng
Shiraz University of Medical Sciences
Journal of Dentistry
2345-6485
2345-6418
2016-09-01
17
3
219
225
41712
Original Article
In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines
Maryam Alsadat Hashemipour
1
Hoda Mehrabizadeh Honarmand
2
Farideh Falsafi
3
Mehrnaz Tahmasebi Arashlo
4
Saied Rajabalian
5
Sayed Amir Hossein Gandjalikhan Nassab
6
Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran and Oral Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Resident of Oral and Maxillofacial Surgery and Oral Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Dentist, Dental and Oral Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Dentist, Dental and Oral Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Medical Student, Kerman Dental and Oral Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Statement of the Problem: Use of cyclooxygenase inhibitors as chemotherapy agents has attracted the attention of a large number of investigators in recent years. Given the importance of cancer therapy, only a limited number of studies have been carried out to investigate the effects of cyclooxygenase inhibitors on specific cell lines.Purpose: This research aimed to determine the in vitro cytotoxic effects of cyclooxygenase inhibitors (COX-1 and COX-2 inhibitors) on KB, Saos-2, 1321N, U-87MG, SFBF-PI 39 cell lines.Materials and Method: Powders of celecoxib, mefenamic acid, aspirin and indometacin were dissolved in the appropriate solvent. The viability of cell lines was carried out by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay technique. Data gathered from four separate experiments were expressed as mean±SD. Statistical significance was defined at p< 0.05 by using analysis of variance. Significant treatment mean values were subjected to post-hoc Tukey’s test.Results: Celecoxib showed marked cytotoxic effects on KB, Saos-2, and 1321N cells, which was significant in comparison with the control group. Celecoxib was not effective in killing U-87MG cell line. Mefenamic acid exerted cytotoxic effects on KB, Saos-2, and 1321N cells, where the viability was approximately 75%. U-87MG cells were resistant to mefenamic acid. Indometacin had the highest rate of activity on U-87MG cells, which was significant in comparison with the control group. Aspirin did not exhibit any activity on these cell lines and was not effective in killing U-87MG, KB, Saos-2, and 1321N cells.Conclusion: This research showed that celecoxib, indometacin, and mefenamic acid have the cytotoxic effects on KB, Saos-2, 1321N and U-87MG cell lines. Therefore, it appears that these drugs can be considered as anti-neoplastic agents in the experimental phase.Keywords ● In Vitro ● Cytotoxicity ● Drug, Celecoxib ● Mefenamic Acid ● Aspirin ● Indometacin ● Cell lines
https://dentjods.sums.ac.ir/article_41712_35f08e1799d0f06cd51826eb9bdca444.pdf
eng
Shiraz University of Medical Sciences
Journal of Dentistry
2345-6485
2345-6418
2016-09-01
17
3
226
232
41713
Original Article
The Effect of Photodynamic Therapy and Diode Laser as Adjunctive Periodontal Therapy on the Inflammatory Mediators Levels in Gingival Crevicular Fluid and Clinical Periodontal Status
Faraz Teymouri
faraz_teymouri@yahoo.com
1
Shirin Zahra Farhad
drsh.farhad@yahoo.com
2
Hedayatollah Golestaneh
golestaneh@dnt.mui.ac.ir
3
Postgraduate Student, Dept. of Periodontics, School of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad university, Isfahan, Iran.
Dept. of Periodontics, School of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Dept. of Periodontics, School of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Statement of the Problem: The presence of bacterial biofilms is the major cause of gingivitis and periodontitis, their mechanical removal is not often enough. Therefore, laser therapy and photodynamic therapy can be effective as adjunctive treatment.Purpose: This study aimed to evaluate the impact of these treatments on the level of gingival crevicular fluid (GCF), inflammatory mediators, and periodontal clinical status.Materials and Method: In this clinical trial, three quadrants were studied in 12 patients with chronic periodontitis aged 30-60 years. The clinical parameters were recorded and GCF samples were taken. After the first phase of periodontal treatment, one of the three quadrants was determined as the control group, one was treated by diode laser, and one underwent photodynamic therapy. The clinical parameters were recorded 2 and 6 weeks later. The data were statistically analyzed by using Friedman, ANOVA, and LSD post-test.Results: Significant reduction was observed over time in the level of Interleukin-1β (IL-1β), Interleukin-17 (IL-17), clinical attachment loss, and pocket depth in the three treatment groups (p< 0.000). The three treatment methods significantly reduced the IL-1β and IL-17 at the baseline, up to 2 weeks, and 2-6 weeks (p< 0.05). Diode laser and photodynamic therapy significantly decreased the average bleeding on probing over time (p< 0.000 and p< 0.002, respectively).Conclusion: Laser and photodynamic therapy reduced the inflammatory mediators (IL-1β and IL-17) and improved the clinical symptoms. Keywords ● Cytokines ● Laser Therapy ● Photosan
https://dentjods.sums.ac.ir/article_41713_75ba78293abe16572180742588e80984.pdf
eng
Shiraz University of Medical Sciences
Journal of Dentistry
2345-6485
2345-6418
2016-09-01
17
3
233
237
41703
Case Report
Incontinentia Pigmenti; a Rare Multisystem Disorder: Case Report of a 10-Year-Old Girl
Rezvan Rafatjoo
1
Amene Taghdisi Kashani
ataghdisi@yahoo.com
2
Dept. of Pediatric Dentistry, School of Dentistry, Hamedan University of Medical Sciences, Hamedan, Iran.
Dept. of Pediatric Dentistry, School of Dentistry, Kashan University of Medical Sciences, Kashan, Iran.
Incontinentia pigmenti is a rare genodermatosis in which the skin involvement occurs in all patients. Additionally, other ectodermal tissues may be affected such as the central nervous system, eyes, hair, nails and teeth. The disease has an X-linked dominant inheritance pattern. But in our case, there was a mutation in the body cells due to incontinentia pigmenti. The dermatological findings occur in four successive phases. We report the case of a 10-year-old female presented cutaneous, dental and ophthalmic characteristic with 3 years follow-up. Dental anomalies such as hypodontia, peg-shaped anterior teeth, malformed primary and permanent teeth, and delayed eruption were seen in our patient.Keywords ● Genetic Diseases ● X-Linked ● Incontinentia Pigmenti ● Dental Anomalies
https://dentjods.sums.ac.ir/article_41703_9073b3e595a905c8c2052ff682d52ad0.pdf
eng
Shiraz University of Medical Sciences
Journal of Dentistry
2345-6485
2345-6418
2016-09-01
17
3
238
241
41705
Case Report
Langer-Giedion Syndrome: a Rare Case Report
Farhin Ali Katge
1
Bhavesh Dahyabhai Rusawat
bhavesh.rusawat@gmail.com
2
Pooja Ravindra Shivasharan
pooja.shivsharan2411@gmail.com
3
Devendra Pandurang Patil
dev1987endra@gmail.com
4
Dept. of Pedodontics & Preventive Dentistry, Terna Dental College, Navi Mumbai, Maharashtra, India.
Dept. of Pedodontics & Preventive Dentistry, Terna Dental College, Navi Mumbai, Maharashtra, India.
Postgraduate Student, Dept. of Pedodontics & Preventive Dentistry, Terna Dental College, Navi Mumbai, India.
Postgraduate Student, Dept. of Pedodontics & Preventive Dentistry, Terna Dental College, Navi Mumbai, India.
Langer-Giedion syndrome is a very uncommon autosomal dominant genetic disorder caused by the deletion of chromosomal material. It is characterized by multiple bony exostosis, short stature, mental retardation, and typical facial features. The characteristic appearance of individuals includes sparse scalp hair, rounded nose, prominent philtral area and thin upper lip. Some cases with this condition have loose skin in childhood which typically resolves with age. Oral and dental manifestations include micrognathia, retrognathia, hypodontia, and malocclusion based on cephalometric analysis. This report presents a case of Langer-Giedion syndrome in a 10-year-old child. Keywords ● Trichorhinophalangeal Syndrome type 2 ● Exostosis ● Hypodontia ● Langer-Giedion Syndrome
https://dentjods.sums.ac.ir/article_41705_7b246779f4c65d720211054be1bec8bd.pdf