TY - JOUR ID - 41751 TI - Efficacy of Human Umbilical Stem Cells Cultured on Polylactic/ Polyglycolic Acid Membrane in the Treatment of Multiple Gingival Recession Defects: a Randomized Controlled Clinical Study JO - Journal of Dentistry JA - DENTJODS LA - en SN - 2345-6485 AU - Zanwar, Kushal AU - Kumar Ganji, Kiran AU - Bhongade, Manohar L AD - Dept. of Periodontics, Sharad Pawar Dental College, Wardha, India Affifilated to Datta Meghe Institute of Medical Sciences, Nagpur, India. AD - Dept. of Periodontics, College of Dentistry, Sakaka Affifilated to Aljouf University, Aljouf Province, KSA. Y1 - 2017 PY - 2017 VL - 18 IS - 2 SP - 95 EP - 103 DO - N2 - Statement of the Problem: Recently allogenic mesenchymal stem cells are proposed to have multipotential progenitor cell capabilities to differentiate into cementoblasts, osteoblasts, and periodontal ligament fibroblasts.Purpose: The aim of the present study was to compare the efficacy of human umbilical stem cells cultured on polylactic acid (PLA), polyglycolic acid (PGA) membrane with PLA/PGA membrane alone in the treatment of multiple gingival recession defects.Materials and Method: A total number of 14 cases of multiple gingival recession (Miller’s Class I or II) located in the anterior region were randomly selected and divided into test (stem cells in combination with PLA/PGA membrane) and control group (PLA/PGA membrane alone). Clinical parameters including gingival recession, probing pocket depth, clinical attachment level, and width of keratinized gingiva were recorded at baseline, and at 6 months postoperative.Results: At baseline, there was 2.28 mm and 2.14mm mean gingival recession at 16 sites and 14 sites in test and control groups respectively. At 6 months post-surgery, test group showed 1.57 mm mean reduction of gingival recession indicating 66% root coverage, while the control group showed 1.24mm mean reduction of gingival recession indicating 57% root coverage.Conclusion: In the present study, the stem cell with PLA/PGA membrane showed significantly higher mean root coverage compared to only PLA/PGA membrane group. Keywords  ● PLA/PGA membrane  ● Stem cells  ● Gingival recession UR - https://dentjods.sums.ac.ir/article_41751.html L1 - https://dentjods.sums.ac.ir/article_41751_fce403fb86e24a1f9c7417abb7100fce.pdf ER -