Background and Aim: Liver cirrhosis is the end stage of liver failure. It is mentioned as one of the main etiologies of morbidity and mortality in the world. The human salivary bacteria may induce oral disorders and interact with other body microbiota. The aim of the present study is to identify the pathogenic bacteria of non-oral origin from the saliva samples of patients with end stage liver failure. Materials and Methods: In a cross sectional study ,the saliva samples of 88 end stage liver disease cases and 84age and sex matched healthy subjects were collected and cultured using gram staining and API20E Kit.Results: According to statistical analysis, the total amount of the non-commensal bacteria was significantly higher in chronic liver failure (CLF) group than controls (p=0.001). Individually, except for escherichia coli, there was no significant difference between both the groups for the presence of other bacteria (P = 0.001), E. coli isolated from the saliva of 15 cases and only 2 controls.Conclusion:Oral cavity may act as a reservoir for enteric bacteria. Adequate oral and general hygiene is necessary to reduce the risk of systemic infection especially in immunocompromised cases.