Expression of CD34 and CD31 in Central and Peripheral Giant Cell Granulomas
Statement of the Problem: Considering the clinical differences between central giant cell granulomas (CGCGs) and peripheral giant cell granulomas (CGCGs) despite their same microscopic feature and possible role of angiogenesis in this issue,
Purpose: The aim of the present study was to compare microvessel density (MVD) between CGCGs and PGCGs of the oral cavity using CD31 and CD34.
Materials and Method: Immunohistochemical staining was performed on 18 PGCGs and 19 CGCGs using a monoclonal antibody against CD34 and CD31. MVD was assessed and compared between the lesions using T-test for statistical analysis. p< 0.05 was considered significant.
Results: The expression levels of both CD34 and CD31 were significantly higher in CGCGs compared to PGCGs (p< 0.002 and p< 0.001, respectively). Significant differences in MVD assessed by both markers were observed between males and females in PGCGs (p< 0.05), but not CGCGs (p< 0.2).
Conclusion: The combined evaluation of old- and newly-formed vessels by pan-endothelial cell markers showed differences between CGCGs and PGCGs, supporting the possible vascular-proliferative nature of the former. Whether this difference has a part in their diverse biologic behaviors and the role which pre-existent vessels play in comparison to neo-formed vasculature, requires further investigation.
View Counter: Abstract | 232 | and PDF | 0 |
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 3.0 License.
pISSN: 2345-6485 eISSN: 2345-6418