Original Article
Saeed Raoofi; Seyedeh Mohadeseh Asadinejad; Hooman Khorshidi
Abstract
Statement of the Problem: The periodontal health and marginal stability of gingiva can be negatively affected by a number of dental conditions in association with deficiency of attached gingiva.Purpose: This study aimed to compare the color and width of tissue grafted by two surgical techniques of keratinized ...
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Statement of the Problem: The periodontal health and marginal stability of gingiva can be negatively affected by a number of dental conditions in association with deficiency of attached gingiva.Purpose: This study aimed to compare the color and width of tissue grafted by two surgical techniques of keratinized gingival augmentation, namely free gingival graft(FGG) and connective tissue graft (CTG) covered by thin mucosal flap .Materials and Method: This clinical trial was performed on 15 adult individuals. The patients showed less than 2mm keratinized gingiva on two different recipient sides. One side was to be treated with CTG as the test group and the other side to be treated with FGG as the control group. The amount of keratinized gingiva before the surgery, size of grafted tissue during the surgery and 6 month after the surgery was documented. Six months after healing, the test and control sides were compared in terms of the width of generated gingiva on both sides, and the color match of the grafted areas with the surrounding gingiva or mucosa. The color of the grafted areas was determined and compared by using both professional evaluation and digital evaluation. Results: In digital evaluation, ∆E (which shows color mismatch) was higher in FGG. In professional evaluation, visual analogue scale (VAS) was used by two blinded periodontists. The mean VASin FGG was less than CTG. The mean increase of gingival width was higher in CTG. The increased width in CTG technique was more than that in FGG technique. This difference was statistically, but not clinically, significant.Conclusion: Higher ∆E in control side and higher mean VAS CTG both showed better color adaptation of CTG side. FGG can be used in case of increasing keratinized gingiva, vestibular depth, and in patients with low smile line without esthetic concerns. However, using connective tissue in the underlying thin mucosal layer is preferred for gingival augmentation if there are adequate vestibule depth and esthetic concerns, like in maxillary canine.
Original Article
Mohammad Reza Talebi Ardakani; Mansour Meimandi; Reza Shaker; Shima Golmohammadi
Abstract
Statement of the Problem: Platelet preparations such as plasma-rich growth factor (PRGF), platelet-rich fibrin (PRF), or enamel matrix derivatives (Emdogain) are commonly used for soft and hard tissue regeneration. However, their comparative effectiveness has not been extensively studied, and a consensus ...
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Statement of the Problem: Platelet preparations such as plasma-rich growth factor (PRGF), platelet-rich fibrin (PRF), or enamel matrix derivatives (Emdogain) are commonly used for soft and hard tissue regeneration. However, their comparative effectiveness has not been extensively studied, and a consensus has yet to be reached on their efficacy.Purpose: The aim of this study was to compare the effect of PRF, PRGF, and Emdogain on the proliferation of human gingival fibroblasts (HGF).Materials and Method: Artificial wounds were made in HGF cell culture after the fibroblasts reached nearly 100% of confluence. The study groups included leukocyte and platelet-rich fibrin (LPRF), pure platelet-rich fibrin (PPRF), PRGF and Emdogain. Stained cells were photographed at 48 h and one week and the percent of wound filling was measured. Statistical analysis was performed by one-way ANOVA and P-values < 0.05 were considered statistically significant.Results: The highest wound filling percentages at both time intervals were observed in the PPRF group, followed by the PRGF. The lowest percentage of wound healing among test groups was observed in the LPRF while Emdogain yielded modest results. However, statistical analysis showed similar wound healing values in PRGF, PPRF, and Emdogain groups.Conclusion: Within the limitations of this study, PRGF, PPRF, and Emdogain were similarly effective in enhancing the fibroblast proliferation and artificial wound closure.
Original Article
Nader Tanideh; Abbas Ali Zareh; Mohammad Mehdi Fani; Maryam Mardani; Farnaz Farrokhi; Ali Talati; Omid Koohi Hosseinabadi; Mahsa Kamali
Abstract
Statement of the Problem: Oral mucositis (OM) is a common inflammatory complication consequent to chemotherapy or radiotherapy in cancer patients that affects their quality of life. Therefore, finding an effective treatment for OM is always imperative.Purpose: The purpose of this experimental study was ...
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Statement of the Problem: Oral mucositis (OM) is a common inflammatory complication consequent to chemotherapy or radiotherapy in cancer patients that affects their quality of life. Therefore, finding an effective treatment for OM is always imperative.Purpose: The purpose of this experimental study was to measure the stereological, anti-inflammatory and antioxidant markers of hydro-alcoholic extract of Pistacia Atlantica (P. atlantica) leaves, Trachyspermum Ammi (T. ammi) fruits and their mixture on induced OM in hamsters.Materials and Method: OM was generated by the method employed by Tanideh et al., in 90 hamsters, by 5-FU (5-fluorouracil 65 mg/kg, IP). All the animals were divided into 5 groups: control, topical gel base, hydro-alcoholic extract 3% of P. atlantica, hydro-alcoholic extract 1% of T. ammi, and a mixture of the extracts of the two plants. On days 13, 15, and 17, the cheek pouch samples were harvested. Stereological scores and the levels of malondialdehyde (MDA), Superoxide dismutase (SOD), myeloperoxidase (MPO), and interleukin-1B (IL-1B) in the pouch tissue were measured.Results: Lower levels of MPO, MDA, and IL-1B and an increase of SOD level were discovered in the mixture-treated group in comparison with other groups. As an aspect of MDA, no significant differences were detected between the topical gel form of P. atlantica and T. ammi groups on days 13 (p= 0.648), 15 (p= 0.981) and 17 (p= 0.540). No variations of MPO were detected among P. atlantica and T. ammi groups on days 13 (p= 0.159) and 15 (p= 0.694); however, the MPO activity of the T. ammi group was significantly lower than the P. atlantica group on day 17 (5.57±0.56 vs. 6.48±0.35 U/ml, p< .001). The volume density of the epithelium increased in the mixture- treated group. (p< 0.05)Conclusion: The results of this study indicated that the mixture of P. atlantica leaves and T. Ammi fruits might be effective in the treatment of OM.
Original Article
Azadeh Andisheh–Tadbir; Aysuda Afshari; Mohammad Javad Ashraf
Abstract
Statement of the Problem: Paxillin is a major cytoskeletal protein aberrantly deregulated in various human cancers and involved in tumor growth and invasion. However, the clinicopathological and prognostic significance of paxillin in salivary gland tumors (SGTs) is still unclear.Purpose: This study was ...
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Statement of the Problem: Paxillin is a major cytoskeletal protein aberrantly deregulated in various human cancers and involved in tumor growth and invasion. However, the clinicopathological and prognostic significance of paxillin in salivary gland tumors (SGTs) is still unclear.Purpose: This study was conducted to evaluate the relationship between paxillin expression and clinicopathological features of patients with SGTs.Materials and Method: In this retrospective study, 50 paraffin-embedded tissue samples which were histologically confirmed as benign (pleomorphic adenoma, PA) or malignant (mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma, ACC) SGTs, and 19 specimens from those with normal salivary gland (NSG) as a control group were assessed for paxillin expression using the immunohistochemistry. The paxillin expression in our samples was scored based on the extent and intensity of immunoreactivity and compared with histological type, clinical stage, and distant metastasis.Results: High paxillin expression was identified in 66% of SGTs whereas all patients with inflammatory NSG showed low expression (p< 0.0001). Although the expression of paxillin in patients with benign and malignant tumors is similar, there is a significant difference between patients with PA, MEC, and ACC with that of the inflammatory NSG (p< 0.0001). Paxillin expression was not correlated with clinicopathological features of patientsConclusion: High expression of paxillin was observed in tumoral tissues compared with the controls that establish an important role of paxillin in SGTs but its prognostic role was unclear and need further evaluation.
Original Article
Parviz Deyhimi; Mahmoud Reza Arefian; Parvin Mahzouni
Articles in Press, Accepted Manuscript, Available Online from 31 December 2018
Abstract
Statement of the Problem: The Biologic behavior and histopathological features of fibromatosis are intermediate between those of fibroma and fibrosarcoma.Purpose: The aim of the present study was to determine useful histopathologic and immunohistochemical characteristics for the differentiation of these ...
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Statement of the Problem: The Biologic behavior and histopathological features of fibromatosis are intermediate between those of fibroma and fibrosarcoma.Purpose: The aim of the present study was to determine useful histopathologic and immunohistochemical characteristics for the differentiation of these lesions.Materials and Method: In this cross-sectional descriptive study, 40 specimens comprising 20 fibrosarcoma and 20 fibromatosis biopsies were selected. The histopathologic characteristics of these lesions were identified and immunohistochemical staining for Ki67 and β-catenin markers was performed. Sections were examined by light microscopy and positively stained cells were counted. Results were analyzed by SPSS 20 using Chi-square test, Mann-whitney test, and t-test (p< 0.05).Results: Statistical significant differences were observed between fibromatosis and fibrosarcoma in terms of distribution frequency, mitotic rate, and herringbone pattern, cellularity, overlapping of nuclei, mean Ki67 score, and atypia rate. The other features including age, gender, necrosis, clarity of nucleoli and mean β-catenin were not significantly different.Conclusion: The present findings suggest the mitotic figures, Ki67, herringbone pattern, cellularity, and atypia are useful to differentiate fibromatosis from fibrosarcoma.Statement of the Problem: The Biologic behavior and histopathological features of fibromatosis are intermediate between those of fibroma and fibrosarcoma.Purpose: The aim of the present study was to determine useful histopathologic and immunohistochemical characteristics for the differentiation of these lesions.Materials and Method: In this cross-sectional descriptive study, 40 specimens comprising 20 fibrosarcoma and 20 fibromatosis biopsies were selected. The histopathologic characteristics of these lesions were identified and immunohistochemical staining for Ki67 and β-catenin markers was performed. Sections were examined by light microscopy and positively stained cells were counted. Results were analyzed by SPSS 20 using Chi-square test, Mann-whitney test, and t-test (p< 0.05).Results: Statistical significant differences were observed between fibromatosis and fibrosarcoma in terms of distribution frequency, mitotic rate, and herringbone pattern, cellularity, overlapping of nuclei, mean Ki67 score, and atypia rate. The other features including age, gender, necrosis, clarity of nucleoli and mean β-catenin were not significantly different.Conclusion: The present findings suggest the mitotic figures, Ki67, herringbone pattern, cellularity, and atypia are useful to differentiate fibromatosis from fibrosarcoma.
Original Article
Farahnaz Sharafddein; Niloofar Haghbin
Abstract
Statement of the Problem: Sufficient bond strength of composite restoration leads to its durability and survival; therefore, preparation of dentin surface for higher bond strength is essential. Purpose: Our aim is to assess the deproteinizing effect of 3% bromelain enzyme and compare it to 4% titanium ...
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Statement of the Problem: Sufficient bond strength of composite restoration leads to its durability and survival; therefore, preparation of dentin surface for higher bond strength is essential. Purpose: Our aim is to assess the deproteinizing effect of 3% bromelain enzyme and compare it to 4% titanium tetrafluoride (TiF4) and 5% sodium hypochlorite (NaOCl) regarding the shear bond strength (SBS) of composite resin to dentin. Materials and Method: A total of 40 intact extracted human maxillary premolars were selected, and the occlusal surfaces of the teeth were sectioned at a depth of 2 mm from dentinoenamel junction (DEJ). The teeth were divided into 4 groups (n=10). In Group 1, the teeth were etched with 37% Phosphoric acid gel. In Group 2, the teeth were etched and deproteinized with 5% NaOCl. In Group 3, the teeth were etched and deproteinized with 4% TiF4. In Group 4, the teeth were etched and deproteinized with 3% Bromelain enzyme. In each specimen, composites with 3 mm diameter and 2 mm height were prepared and cured. The test specimens were then stored in distilled water at room temperature for 7 days before conducting the SBS test (MPa). By Universal Testing Machine at a cross-head speed of 1 mm/min, the results were analyzed using one-way ANOVA and Tukey test. Results: One-way ANOVA test demonstrated that pretreatment of dentin with a bromelain enzyme, TiF4 solution, or NaOCl was not statistically different regarding SBS to dentin (p= 0.790). Conclusion: 3% bromelain enzyme can be as effective as TiF4 and NaOCl and phosphoric acid 37% in terms of the SBS of composite resin to dentin.
Original Article
Zahra Hashemi Ardakani; Amir Ali Reza Khaledi; Mina Mohghegh; Seyed Ahmad Ghoreishian; Sahar Khorsandipour
Abstract
Statement of the Problem: One of the major concerns about all ceramic crowns is their fracture resistance. Purpose: The purpose of this in vitro study was to evaluate the effect of two marginal designs (shoulder 90°, shoulder 135°) on the fracture resistance of zirconia copings. Materials and ...
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Statement of the Problem: One of the major concerns about all ceramic crowns is their fracture resistance. Purpose: The purpose of this in vitro study was to evaluate the effect of two marginal designs (shoulder 90°, shoulder 135°) on the fracture resistance of zirconia copings. Materials and Method: 20 brass dies were prepared using milling machine: 10 with 1mm width shoulder 90° marginal design and the other 10 with 1mm width shoulder 135° finish line design. (n=10) zirconia cores with 0.5mm thickness and 30μm cement space were fabricated on brass dies. The copings were cemented on the dies and underwent a fracture test with a universal testing machine. Data were analyzed using Mann-Whitney test. Results: The mean value of fracture resistance for shoulder 90° finish line design were 368.3±109.4 N and for shoulder 135° finish line design were 518.4±115.5 N. Data analysis revealed a statistically significant difference between groups (p< 0.05). Conclusion: The results of this study showed that the finish line design of zirconia copings influences their fracture resistance. A 135° shoulder finish line design can improve the fracture resistance of zirconia crowns.
Original Article
Najme Etemadi
Abstract
Statement of the Problem: The most common cause of endodontic treatment failures is improper coronal sealing. Therefore, besides to proper root sealing, coronal sealing which is supported by a proper restoration has a major role in endodontic treatment success, and coronal microleakage should be considered ...
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Statement of the Problem: The most common cause of endodontic treatment failures is improper coronal sealing. Therefore, besides to proper root sealing, coronal sealing which is supported by a proper restoration has a major role in endodontic treatment success, and coronal microleakage should be considered as an etiologic factor in endodontic treatment failure. Infact this leakage shows its affect by penetration through the coronal part of root canal, therefore the aim of this study was to evaluate the effect of glass-ionomer (GI) thickness as a coronal barrier on microleakage after endodontic treatment.
Purpose: This study aimed to evaluate the coronal microleakage in GI-obturated root canals in endodontically treated teeth using different thicknesses of GI.
Materials and Method: Forty-five single-rooted extracted human teeth with single canals were collected and disinfected with 0.5% chloramine solution. Endodontic treatment was undertaken and the teeth were divided into 3 groups: group 1: 1 mm of gutta-percha, group 2: 2 mm of gutta-percha and group 3: 3 mm of gutta-percha was removed and GI respectively was replaced at 1-, 2- and 3-mm thicknesses. Then subgroups were placed in methylene blue dye and the microleakage was assessed using dye penetration.
Results: The mean dye penetration in groups 1, 2 and 3 were 5.1, 3.7 and 2.9, respectively, with statistically significant differences. Group 1 exhibited the highest amount of dye penetration while group 3 showed the least one. Also comparisons between groups showed a significant difference between groups 1 and 2 in mean dye penetration (p= 0.002) but this was not significant between groups 2 and 3 (p= 0.098).
Conclusion: The results of the present study indicated that a thicker GI layer might be associated with a decrease in coronal microleakage. Although the results showed that GI at 3-mm thickness resulted in the best protective effect on coronal microleakage in endodontically treated teeth, further studies are needed to confirm these results.
Original Article
Golpar Radafshar; Marziyeh Movahedi Amiri
Abstract
Statement of the Problem: Information on patient-centered outcomes of periodontal disease and the impact of different periodontal treatment phases on the life quality of periodontal patients is limited. Purpose: This study sought to compare patients’ perception of their oral health-related quality ...
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Statement of the Problem: Information on patient-centered outcomes of periodontal disease and the impact of different periodontal treatment phases on the life quality of periodontal patients is limited. Purpose: This study sought to compare patients’ perception of their oral health-related quality of life (OHQoL) following one-stage full mouth disinfection (OSFMD) and surgical periodontal treatment. Materials and Method: A single group, two-phase, pre-and post-interventional study design was used. Subjects were recruited from moderate to severe chronic periodontitis patients referred to a private clinic. At baseline and after each treatment phase, periodontal parameters were recorded by a blind examiner. Patients received OSFMD, followed by periodontal flap surgeries and completed the validated Iranian version of the OHIP-49 questionnaire (OHIP-35-IR) at three time points (baseline, two weeks post-initial therapy and after completion of surgical phase). Data were analyzed using repeated measure ANOVA, paired and independent t-tests, and multivariate regression analysis by SPSS software version 21. Results: 38 patients (14 men, 24 women, mean age 40.30±11.93) completed the study. Periodontal parameters showed progressive improvement from baseline to the end of the study (p<0.05). The total mean OHIP-35-IR score at baseline (89.25±19.26) was significantly improved (reduced) compared to each treatment phase (75.63±17.15 and 74.22±15.46, respectively; p< 0.001), with no significant difference between treatments. Improvements in subdomains of psychological discomfort, functional limitation, physical pain, and handicap accounted for the changes. The effect size was calculated to be 0.80 for the first and 0.66 for the second treatment phases. Conclusion: Within limits, OSFMD and periodontal surgical treatment have positive impacts on the OHQoL of patients. Intensive periodontal non-surgical treatment is as effective as surgical intervention for achieving desirable patient-centered outcomes.
Original Article
Nooshin Sadat Shojaee; Ehsan Vakilinezhad; Mohammad Mehdi Shokouhui
Abstract
Statement of the problem: The complete removal of filling material is an important step to regain access to the entire canal and facilitate the disinfection of the root canal system. Rotary nickel–titanium (NiTi) instruments systems have been proposed as an effective removal technique for root ...
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Statement of the problem: The complete removal of filling material is an important step to regain access to the entire canal and facilitate the disinfection of the root canal system. Rotary nickel–titanium (NiTi) instruments systems have been proposed as an effective removal technique for root canal retreatment.
Purpose: The aim of this study was to evaluate the efficacy of Neolix rotary system and ProTaper universal retreatment system in the removal of gutta-percha combined with two different sealers.
Materials and Method: Eighty extracted human permanent mandibular premolarswere prepared using the ProTaper universal rotary system to an apical size 30(F3/0.06). The specimens were randomly divided into 4 groups (n=20) and subsequently filled with lateral condensation of gutta-percha and two sealers: AH-26 and Sure-Seal Root. The teeth were stored for 4 weeks at 37 °C and 100% humidity and then retreated by one of the following rotary systems: Neolix or ProTaper universal retreatment system. Teeth were then grooved and monitored under a stereomicroscope with 8× magnification. The images were transferred to the computer and the amount of filling material that remained on the root canal walls was scored using AutoCAD 2017 version 1.1software. Results were analyzed using one-way analysis of variance test and post hoc Tukey-HSD test (p< 0.05).
Results: The mean percentage of remaining gutta-percha and sealer was significantly higher in apical third in all groups (P<0.01). Post hoc Tukey test showed that there is significantly higher residual filling material in the group filled with gutta-percha and Sure-Seal Root sealer and retreated by Neoniti rotary system compared with other groups in both coronal and middle third of the canal.
Conclusion: The Neoniti rotary system was as effective as Protaper universal retreatment system in retreatment of gutta-percha and AH-26 sealer but was significantly less effective in groups obturated with Sure-Seal Root sealer.
Original Article
Javad Faryabi; Mohsen Barzegar; Shiva Pouradeli
Abstract
Statement of the Problem: Swelling of the surrounding tissue of surgical site is one of the most common, devastating effects after maxillofacial surgery and can have an effect on quality of life and the patients' satisfaction. Purpose: The purpose of this study was to investigate the effect of a custom-made ...
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Statement of the Problem: Swelling of the surrounding tissue of surgical site is one of the most common, devastating effects after maxillofacial surgery and can have an effect on quality of life and the patients' satisfaction. Purpose: The purpose of this study was to investigate the effect of a custom-made appliance by the method of Computer-aided design/Computer-aided manufacturing (CAD/CAM) compared with conventional dressing for reducing facial swelling after maxillofacial surgery. Materials and Method: This study accomplished in 14 patients voluntarily referred to the Department of Oral and Maxillofacial Surgery at Bahonar hospital in Kerman. These patients were the candidate for surgical treatment of similar bilateral facial fractures (10 patients) and orthognathic surgery (4 patients). Facial Computed tomography (CT) scans of the patients were taken to build up a custom-made appliance. Based on three-dimensional reconstruction from facial CT scan data, custom-made appliance was designed and built. Swelling on one side with custom-made appliance and on the opposite side with conventional dressing measured with paper tape graded before surgery, immediately after surgery, 24 hours, 48 hours, and 7 days later, we divided the patients into two groups: trauma and orthognathic surgical procedures Results: Based on the defined landmarks, all of the measurements were performed on both sides. Statistical analyses do not show any asymmetry before surgery (p= 0.48). In addition, there was no significant difference between two methods of dressing on the day of surgery and a day later (p= 0.084, p= 0.09), but there was a significant difference between two methods of dressing on second and seventh days. The Swelling has decreased faster and further in our new method. Conclusion: Regarding the exact adaptation to the surgical site on facial skin, using custom-made appliance by the method of CAD/CAM could be an effective tool that reduces swelling after maxillofacial surgery.
Original Article
Moein Zarei; Saeed Karbasi; Fatemeh Sari Aslani; Shahrokh Zare; Omid Koohi-Hosseinabad; Nader Tanideh
Abstract
Statement of the Problem: Tissue engineering was an idea and today becomes a potential therapy for several tissues in dentistry such as Periodontal Disease and oral mucosa. Purpose: Periodontal regeneration is one of the earliest clinical disciplines that have achieved the therapeutic application of ...
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Statement of the Problem: Tissue engineering was an idea and today becomes a potential therapy for several tissues in dentistry such as Periodontal Disease and oral mucosa. Purpose: Periodontal regeneration is one of the earliest clinical disciplines that have achieved the therapeutic application of tissue engineering. The aim of the presence study was to prepare electrospun Poly(3-hydroxybutyrate) (PHB)/1% Carbon nanotubes (CNTs) scaffolds for periodontal regeneration. Materials and Method: 1% w/v of CNTs was added to the polymer solutions and electrospinning. Physical properties of the scaffolds were evaluated by Scanning electron microscopy (SEM) and universal testing machine. Chemical characterization of the scaffolds was also assessed by Fourier-transform infrared spectroscopy (FTIR). Biological properties of the scaffolds were also evaluated in vitro by culturing periodontal ligament stem cells (PDLSCs) on the scaffolds for 10 days and in vivo by Implanting the scaffolds in rat model for 5 weeks. Results: Results showed that the scaffolds were mimicked fibrous connective tissue of the (PDL). CNTs improved the mechanical properties similar to 23-55 years old human PDL. In vitro biocompatibility study showed more attachment and proliferation of the PDLSCs for PHB/1%CNTs scaffolds compared to the PHB controls. In vivo study showed that CNTs in the scaffolds caused mild foreign body type giant cell reaction, moderate vascularization, and mild inflammation. Conclusion: In conclusion, the results showed that the PHB/1%CNTs composite scaffolds may be potentially useful in periodontal regeneration.
Original Article
Atena Shiva; Shahin Arab; Seyyed Jaber Mousavi; Ali Zamanian; Avideh Maboodi
Abstract
Statement of the Problem: Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease with unclear etiology while a few cases of disease become malignant.
Purpose: This study aimed to evaluate the level of nitric oxide (NOx) and C-reactive protein (CRP) as oxidative stress and inflammation ...
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Statement of the Problem: Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease with unclear etiology while a few cases of disease become malignant.
Purpose: This study aimed to evaluate the level of nitric oxide (NOx) and C-reactive protein (CRP) as oxidative stress and inflammation status in sample of OLP patients.
Materials and Method: In this case-control study, serum and salivary NOx and CRP levels were evaluated in twenty two OLP patients as the case group confirmed by clinical and histopathological diagnosis, and twenty two healthy control groups collected from Tooba oral pathology laboratory in Sari in 2016. The data were analyzed by using independent-samples t-test, Mann-Whitney U-test and Chi-square by using SPSS version 21. The statistical significant level was considered at p< 0.05.
Results: Salivary and serum NOx levels in case group showed statistically significantly higher than healthy control group (p= 0.035 and p= 0.001, respectively). CRP values were significantly higher both in serum (p= 0.001) and in saliva (p= 0.035). A significant correlation was found between CRP and NOx values in serum (r= 0.521, p= 0.0001) and saliva (r= 0.427, p= 0.045).
Conclusion: Oxidative stress causes damage to organs in the human body. Correct understanding of oxidative stress and its association with free radicals and inflammatory markers related to oral disease are important for effective treatments. The results of the study supported the effects of NOx and CRP levels in pathogenesis of OLP. Regarding antioxidant drugs could probably be considered in the treatment of OLP.
Original Article
Parastou Behrouzi; Haleh Heshmat; Maryam Hoorizad Ganjkar; Seyedeh Farnaz Tabatabaei; Mohammad Javad Kharazifard
Abstract
Statement of the Problem: The progression of incipient carious lesions may be simply prevented by non-invasive remineralization of lesions, eliminating the need for invasive and high-cost restorative procedures. Purpose: This study aimed to assess the effect of two commonly used remineralizing agents ...
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Statement of the Problem: The progression of incipient carious lesions may be simply prevented by non-invasive remineralization of lesions, eliminating the need for invasive and high-cost restorative procedures. Purpose: This study aimed to assess the effect of two commonly used remineralizing agents and resin infiltration on surface micro hardness of incipient enamel lesions at different time points. Materials and Method: In this in vitro study 45 intact human maxillary central incisors were selected. After disinfection, enamel samples measuring 5x5x2.5 mm were cut out of the labial surface of the teeth. The surface of samples was polished and they were mounted in auto-polymerizing acrylic resin. According to Amaechi’s method samples were immersed in acidified hydroxyethylcellulose system (pH = 4.5) for 96 hours to induce white spot lesions (WSLs). The baseline surface micro hardness of samples was measured using a Vickers hardness tester, then the samples were randomly divided into three groups (n=15) based on different remineralization methods: MI-Paste Plus, Remin Pro and ICON-Infiltrant according to the manufacturer’s instructions. All samples were stored in anti-dry mouth treatment agent during the experiment and their surface hardness was measured at 15 days (T1) and 20 weeks (T2). Results: The hardness of samples in MI-Paste Plus and Remin Pro groups significantly increased at both T1 and T2 (p< 0.001) but this increase was not significant in ICON group (p> 0.05). Conclusion: MI-Paste Plus and Remin Pro can efficiently increase the hardness of incipient enamel lesions.
Case Report
Maryam Sharifi; Fatemeh Jahanimoghadam
Abstract
Goldenhar syndrome (GHS) is a complex syndrome characterized by relation of mandibular hypoplasia, abnormality of the ear, ocular dermoid and vertebral disorders and hemi facial macrosomia. Treatment protocol depends on the patient’s age and systemic clinical presentations, with a multidisciplinary ...
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Goldenhar syndrome (GHS) is a complex syndrome characterized by relation of mandibular hypoplasia, abnormality of the ear, ocular dermoid and vertebral disorders and hemi facial macrosomia. Treatment protocol depends on the patient’s age and systemic clinical presentations, with a multidisciplinary method often being required. This case report describes a typical 6-year-old female patient who presented to the Department of Pediatric Dentistry, Faculty of Dentistry, University of Medical Sciences, Kerman, Iran with mandibular hypoplasia, facial asymmetry, ear tags and ocular dermoid after plastic surgery. Diagnosis was based on clinical aspects, radiology and laboratory findings. GHS is a developmental complaint that can disturb many aspects of the patient's life, so needs fast treatment from birth.
Case Report
Soudabeh Sargolzaei; Saede Atarbashi-Moghadam; Aliasghar Roohi
Abstract
Ameloblastomas demonstrate various clinical and microscopic patterns. They typically have been described as possessing three biologic variants including solid, cystic (unicystic) and peripheral, of which about 13% to 21% of all cases are unicystic. Granular cell subtype is a rare variant especially when ...
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Ameloblastomas demonstrate various clinical and microscopic patterns. They typically have been described as possessing three biologic variants including solid, cystic (unicystic) and peripheral, of which about 13% to 21% of all cases are unicystic. Granular cell subtype is a rare variant especially when both the inner and peripheral layers of tumoral islands composed exclusively of eosinophilic granular cells. The purpose of this case report is to present a unique case of cystic ameloblastoma with an unusual radiographic and microscopic pattern affecting a 25-year-old female. Awareness of these rare histopathologic features for oral pathologist is essential to help correct diagnosis.
Case Report
Hassan Mir Mohammad Sadeghi; Fatemeh Mashhadi Abbas; Nasim Taghavi; Nazan Baharnoori
Abstract
Ewing's sarcoma is an uncommon malignancy primarily affecting bone tissue and usually occurs in adolescents and young adults. This paper reports a rare case of extra-skeletal Ewing’s sarcoma of the oral cavity soft tissue. In the clinical examination, a mass of 1.5×1.5 cm in diameter was observed ...
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Ewing's sarcoma is an uncommon malignancy primarily affecting bone tissue and usually occurs in adolescents and young adults. This paper reports a rare case of extra-skeletal Ewing’s sarcoma of the oral cavity soft tissue. In the clinical examination, a mass of 1.5×1.5 cm in diameter was observed in the right mandibular vestibule. Radiographic examination revealed no involvement of mandible. Microscopically, the tumor was composed of malignant small round cell tumor that exhibited immunoreactivity for CD99. The patient was subjected to enucleation surgery under local anesthesia, prognosis was excellent, and the patient remained symptom-free after 13 months.
Case Report
Saede Atarbashi-Moghadam; Ali Lotfi; Mohammad Moshref; Fazele Atarbashi-Moghadam
Abstract
Melanotic neuroectodermal tumor of infancy is a rare, rapidly growing, painless, pigmented neoplasm with neural crest derivation. It usually occurs during the first year of life and there is a prominent predilection for the maxilla. The purpose of the present report is to describe additional case of ...
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Melanotic neuroectodermal tumor of infancy is a rare, rapidly growing, painless, pigmented neoplasm with neural crest derivation. It usually occurs during the first year of life and there is a prominent predilection for the maxilla. The purpose of the present report is to describe additional case of melanotic neuroectodermal tumor of infancy of maxilla in a 6-month-old infant male. The treatment included surgical excision with safe margins. No attempt was made for immediate grafting of the surgery site due to high proliferation rate of tissues and self-renewal during infancy. The facial growth was normal and the surgical cleft was tightly closed. Due to the rarity of tumor, essential knowledge on characteristics of this lesion would contribute to a proper diagnosis and benefit treatment planning.
Case Report
Mala Kamboj; Achla Bharti Yadav; Anjali Narwal; J. Neera
Abstract
Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic neoplasm which is exclusively epithelial in its tissue of origin. Many cases of CEOTs are associated with impacted tooth and simulate dentigerous cyst, radiographically. The histologic features of CEOT are unique, however, among ...
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Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic neoplasm which is exclusively epithelial in its tissue of origin. Many cases of CEOTs are associated with impacted tooth and simulate dentigerous cyst, radiographically. The histologic features of CEOT are unique, however, among its various histologic subtypes, the cystic variant is a rare and less well understood entity. Our report elucidates a cystic variant of CEOT in the maxilla of a 16-year-old male that presents clinical and radiologic findings conscientious to dentigerous cyst; but histopathological diagnosis came out to be a gold standard in identifying this rare tumor. Herein, the authors describe the clinicopathologic features of this rare entity, highlighting histomorphologic findings along with reviewing of other reported cases.
Case Report
Nazanin Mahdavi; Neda Kardooni Khoozestani; Mahboube Hasheminasab; Nika Soltani
Abstract
Calcifying odontogenic cyst (COC) is an uncommon odontogenic lesion that represents less than 2% of all odontogenic cysts and tumors. It usually occurs in incisor and canine areas during the second to fourth decades of life. It can be associated with other lesions like odontoma, Ameloblastic Fibroma, ...
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Calcifying odontogenic cyst (COC) is an uncommon odontogenic lesion that represents less than 2% of all odontogenic cysts and tumors. It usually occurs in incisor and canine areas during the second to fourth decades of life. It can be associated with other lesions like odontoma, Ameloblastic Fibroma, Ameloblastoma, Adenomatoid odontogenic tumors, Odontoameloblastoma, and Odontogenic Myxoma. Ameloblastic fibroma is a truly mixed tumor usually diagnosed within the posterior mandible during the first two decades of life. In the present article, a hybrid odontogenic tumor composed of COC and Ameloblastic Fibroma in a 14-year-old white Persian female is described.
Case Report
Molook Torabi; Mehrnaz Karimi Afshar; Hoda Barati
Abstract
Melkersson-Rosenthal syndrome (MRS) is a rare neurological condition that includes a triad of symptoms: recurring facial paralysis, orofacial swelling and fissured tongue. The diagnosis and treatment of this syndrome is difficult, because the classic triad is rarely possible to see in its complete ...
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Melkersson-Rosenthal syndrome (MRS) is a rare neurological condition that includes a triad of symptoms: recurring facial paralysis, orofacial swelling and fissured tongue. The diagnosis and treatment of this syndrome is difficult, because the classic triad is rarely possible to see in its complete form. The etiology of MRS is unknown, but it is thought to be caused by various factors such as infections, genetic predisposition, immune deficiency, food intolerance and stress. This case report presents a 22 years old male patient with classical triad of MRS.
Case Report
Mahesh Gandhewar; Tejaswini Bankar; Audrey Selecman; Swati Ahuja
Abstract
Naso-maxillary defects may affect patients’ speech, mastication, swallowing, breathing, quality of life, psychology, and social behaviour. A combination of surgical reconstruction and prosthetic rehabilitation is frequently required torestore optimal function and esthetics. Of particular concern ...
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Naso-maxillary defects may affect patients’ speech, mastication, swallowing, breathing, quality of life, psychology, and social behaviour. A combination of surgical reconstruction and prosthetic rehabilitation is frequently required torestore optimal function and esthetics. Of particular concern is the size, weight and contour of the prosthesis, as it can drastically affect comfort, retention, masticatory function and ease of insertion and removal. This clinical case report describes the prosthodontic rehabilitation of a partially edentulous patient with a naso-maxillary defect (Aramany’s class VI) with a two-component prosthesisjoined by magnets.
Case Report
Amir Shirani; atefeh Akhani; Vahid Esfahanian; Shahab Etemadi; Mohammad Reza Mohajeri
Abstract
The jaw plasmacytoma is a very rare condition which its diagnosis is difficult in clinical routine. Up to now, less than 60 cases of jaw plasmacytoma have been reported in the literature. In the present case report, we reported a rare case of jaw plasmacytoma in a 42-year-old female which was misdiagnosed ...
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The jaw plasmacytoma is a very rare condition which its diagnosis is difficult in clinical routine. Up to now, less than 60 cases of jaw plasmacytoma have been reported in the literature. In the present case report, we reported a rare case of jaw plasmacytoma in a 42-year-old female which was misdiagnosed with dental granuloma and abscess. The diagnosis of plasmacytoma was done by immunohistochemistry (IHC) evaluation following a cone beam computed tomography (CBCT) assessment. The patient was treated with radiotherapy and is disease free after 2 years.
Technical Report
Andrew Johnson; Vinay Jain; Swati Ahuja
Abstract
Immediate placement of dental implants presents many challenges, especially when partial or complete fixed restorations are the intended prosthetic outcome. With modern advancements in CAD/CAM technology, the ease and predictability of such complex cases is vastly improved. However, certain clinical ...
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Immediate placement of dental implants presents many challenges, especially when partial or complete fixed restorations are the intended prosthetic outcome. With modern advancements in CAD/CAM technology, the ease and predictability of such complex cases is vastly improved. However, certain clinical situations remain that preclude the traditional implementation of this controlled approach to implant planning/placement and the current solutions to these problems each impose some level of compromise. This article describes a technique permitting both prosthetically-driven implant planning and increased surgical guide accuracy in situations where existing hopeless teeth would otherwise impede optimal treatment.
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