@article { author = {Mardani, Maryam and Torabi Ardakani, Shiva and Dastgheib, Ladan and Hamidizadeh, Nasrin}, title = {Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus}, journal = {Journal of Dentistry}, volume = {21}, number = {4}, pages = {330-334}, year = {2020}, publisher = {Shiraz University of Medical Sciences}, issn = {2345-6485}, eissn = {2345-6418}, doi = {10.30476/dentjods.2020.84667.1096}, abstract = {Statement of the Problem: Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues, which its etiology and pathogenesis are unclear. Cytokines play an important role in the initiation, maintenance of inflammatory and intercellular cross-talk. Purpose: We assessed serum levels of IL-22 in patients with oral and cutaneous lichen planus and made comparison with healthy individuals. Materials and Method: Peripheral blood samples of 40 patients with lichen planus disease, included two groups of oral lichen planus (n=20) and cutaneous lichen planus (n=20) were compared with 32 healthy individuals. Serum samples were prepared from LP patients, using a commercial ELISA Kit, IL-22 concentration was measured in each serum sample. The obtained data were then analyzed using the Kruskal-Wallis one-way analysis of variance. Results: IL-22 serums level was significantly higher in patients with oral lichen planus than the healthy control group (p < 0.001). No statistically significant differences were observed in serum levels of IL-22 in cutaneous lichen planus patients compared to the controls (p = 0.183). Conclusion: Increased IL-22 serum levels in patients with oral lichen planus may play an important role in the pathogenesis of oral Lichen planus. The administration of the recombinant or antagonist of IL-22 could be a new therapeutic opportunity in the treatment of oral lichen planus.}, keywords = {IL-22,Oral lichen planus,Cutaneous lichen planus,serum}, url = {https://dentjods.sums.ac.ir/article_46238.html}, eprint = {https://dentjods.sums.ac.ir/article_46238_a1a9ed1ad147ac8fc934a460e022de24.pdf} }