%0 Journal Article %T Evaluation of Plasma Isoprostane in Patients with Oral Lichen Planus %J Journal of Dentistry %I Shiraz University of Medical Sciences %Z 2345-6485 %A Amirchaghmaghi, Maryam %A Hashemy, Seyed Isaac %A Alirezaei, Banafsheh %A Jahed Keyhani, Fereshteh %A Kargozar, Sanaz %A Vasigh, Samaneh %A Gharaei, Shideh %A Pakfetrat, Atessa %D 2016 %\ 03/01/2016 %V 17 %N 1 %P 21-25 %! Evaluation of Plasma Isoprostane in Patients with Oral Lichen Planus %R %X Statement of the Problems: Lichen planus is a chronic inflammatory disease. Free radicals and reactive oxygen species play important roles in pathogenesis of oral lichen planus (OLP). Isoprostanes show oxidative stress and are formed by free-radical mediated lipid peroxidation of arachidonic acid and cell membrane phospholipids.Purpose: This study was conducted to evaluate the plasma level of 8-isoprostane in patients suffering from erosive and non-erosive forms of OLP.Materials and Method: In this case-control study, 31 patients with OLP and 30 control subjects were enrolled. Plasma samples were obtained and the level of 8-isoprostane was measured with Sandwich enzyme-linked immunosorbent assay (ELISA) in both groups. The data were analyzed by using two-sample t-test, chi-square and ANOVA tests.Results: The results showed significant increase in the plasma level of 8-isoprostane in OLP group compared with the control group. The results of independent t-test revealed no significant correlation between the plasma level of isoprostane and sex, smoking, or previous treatment.Conclusion: Based on the findings of this study, oxidative stress was increased in patients with OLP, reflected by higher concentrations of 8-isoprostane in plasma.Key Words: Oral Lichen Planus; Isoprostane; Oxidative Stress %U https://dentjods.sums.ac.ir/article_41682_add04d51e81a0f5a1ee91f618b6b8d8a.pdf