%0 Journal Article %T Topical Olive Leaf Extract Improves Healing of Oral Mucositis in Golden Hamsters %J Journal of Dentistry %I Shiraz University of Medical Sciences %Z 2345-6485 %A Showraki, Najmeh %A Mardani, Maryam %A Emamghoreishi, Masoumeh %A Andishe-Tadbir, Azadeh %A Aram, Alireza %A Mehriar, Peiman %A Omidi, Mahmoud %A Sepehrimanesh, Masood %A Koohi-Hosseinabadi, Omid %A Tanideh, Nader %D 2016 %\ 12/01/2016 %V 17 %N 4 %P 335-342 %! Topical Olive Leaf Extract Improves Healing of Oral Mucositis in Golden Hamsters %R %X Statement of the Problem: Oral mucositis (OM) is a common side effect of anti-cancer drugs and needs significant attention for its prevention.Purpose: This study aimed to evaluate the healing effects of olive leaf extract on 5-fluorouracil-induced OM in golden hamster.Materials and Method: OM was induced in 63 male golden hamsters by the combination of 5-fluorouracil injections (days 0, 5 and 10) and the abrasion of the cheek pouch (days 3 and 4). On day 12, hamsters were received topical olive leaf extract ointment, base of ointment, or no treatment (control) for 5 days. Histopathology evaluations, blood examinations, and tissue malondialdehyde level measurement were performed 1, 3 and 5 days after treatments.Results: Histopathology score and tissue malondialdehyde level were significantly lower in olive leaf extract treated group in comparison with control and base groups (p= 0.000). Significant decreases in white blood cell, hemoglobin, hematocrit , and mean corpuscular volume and an increase in mean corpuscular hemoglobin concentration were observed in olive leaf extract treated group in comparison with control and base groups (p< 0.05).Conclusion: Our findings demonstrated that daily application of olive leaf extract ointment had healing effect on 5-fluorouracil induced OM in hamsters. Moreover, the beneficial effect of olive leaf extract on OM might be due to its antioxidant and anti-inflammatory properties.Keywords ● 5- fluorouracil  ● Anti-inflammatory  ● Antioxidant  ● Olive Leaf  ● Oral Mucositis  %U https://dentjods.sums.ac.ir/article_41729_4c0ab0e531aebc57219ead9e59eb3507.pdf