%0 Journal Article %T HER2/neu and αSMA Expression in Oral Squamous Cell Carcinoma %J Journal of Dentistry %I Shiraz University of Medical Sciences %Z 2345-6485 %A Seifi, Safoura %A Shafaie, Sh. %D 2011 %\ 03/01/2011 %V 12 %N 1 %P 11-18 %! HER2/neu and αSMA Expression in Oral Squamous Cell Carcinoma %K Squamous cell carcinoma %K HER2/neu %K αSMA %K Myofibroblast %R %X Statement of Problem: Squamous cell carcinoma (SCC) is the most common cancer of the mouth, but its pathogenesis is unknown. HER2/neu is a protoncogene with homologue sequence with EGF. αSMA is a smooth muscle specific actin which indicates the existence of  myofibroblasts in the oral cancer stroma. Purpose:  This study aimed to measure the frequency of Her2/neu and (alpha) αSMA in oral SCC. Materials and Method: For this study, 18 paraffinized blocks of OSCC were immunostained with Anti HER2/neu, Anti (Alpha) SMA. Percentage and degree of the epithelial cells staining and percentage staining of myofibroblasts were considered. The results of the study were analyzed using kappa and X2. Results: From 18 cases of OSCC, 3 and 12 cases were positive with HER2/neu and αSMA, respectively. In the normal oral mucosa, one case was positive (Score 2) with HER2/neu but αSMA positive myofibroblasts were not seen in the stroma of OSCC. A significant difference was seen in αSMA expression in OSCC and the normal oral mucosa ( p =0.002). No significant difference was found in HER2/neu expression in OSCC and normal mucosa ( p >0.05). Conclusion: The results of this study suggest that αSMA has an effective role in pathogenesis and aggressive behavior of OSCC but HER2/neu has no main role in this type of oral cancer.  %U https://dentjods.sums.ac.ir/article_46258_2560f5654778f5ddae45843a0cf8c0ab.pdf