TY - JOUR ID - 41729 TI - Topical Olive Leaf Extract Improves Healing of Oral Mucositis in Golden Hamsters JO - Journal of Dentistry JA - DENTJODS LA - en SN - 2345-6485 AU - Showraki, Najmeh AU - Mardani, Maryam AU - Emamghoreishi, Masoumeh AU - Andishe-Tadbir, Azadeh AU - Aram, Alireza AU - Mehriar, Peiman AU - Omidi, Mahmoud AU - Sepehrimanesh, Masood AU - Koohi-Hosseinabadi, Omid AU - Tanideh, Nader AD - Post Graduate Student, Dept. of Oral Medicine, School of Dentistry, Shiraz University of Medical sciences, Shiraz, Iran. AD - Dept. of Oral Medicine, School of Dentistry, Shiraz University of Medical sciences, Shiraz, Iran. AD - Dept. of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Dept. of Oral and Maxillofacial Pathology, Prevention and Treatment of Oral and Dental Diseases Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Transgenic Technologies Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. AD - School of Dentistry, University of Southern California, Los Angeles, USA. AD - Dept. of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Laboratory Animals Center, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Dept. of Pharmacology, School of Medicine, Transgenic Technologies Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Y1 - 2016 PY - 2016 VL - 17 IS - 4 SP - 335 EP - 342 DO - N2 - Statement of the Problem: Oral mucositis (OM) is a common side effect of anti-cancer drugs and needs significant attention for its prevention.Purpose: This study aimed to evaluate the healing effects of olive leaf extract on 5-fluorouracil-induced OM in golden hamster.Materials and Method: OM was induced in 63 male golden hamsters by the combination of 5-fluorouracil injections (days 0, 5 and 10) and the abrasion of the cheek pouch (days 3 and 4). On day 12, hamsters were received topical olive leaf extract ointment, base of ointment, or no treatment (control) for 5 days. Histopathology evaluations, blood examinations, and tissue malondialdehyde level measurement were performed 1, 3 and 5 days after treatments.Results: Histopathology score and tissue malondialdehyde level were significantly lower in olive leaf extract treated group in comparison with control and base groups (p= 0.000). Significant decreases in white blood cell, hemoglobin, hematocrit , and mean corpuscular volume and an increase in mean corpuscular hemoglobin concentration were observed in olive leaf extract treated group in comparison with control and base groups (p< 0.05).Conclusion: Our findings demonstrated that daily application of olive leaf extract ointment had healing effect on 5-fluorouracil induced OM in hamsters. Moreover, the beneficial effect of olive leaf extract on OM might be due to its antioxidant and anti-inflammatory properties.Keywords ● 5- fluorouracil  ● Anti-inflammatory  ● Antioxidant  ● Olive Leaf  ● Oral Mucositis  UR - https://dentjods.sums.ac.ir/article_41729.html L1 - https://dentjods.sums.ac.ir/article_41729_4c0ab0e531aebc57219ead9e59eb3507.pdf ER -