TY - JOUR ID - 44557 TI - Expression of CD34 and CD31 in Central and Peripheral Giant Cell Granulomas JO - Journal of Dentistry JA - DENTJODS LA - en SN - 2345-6485 AU - Sadri, Donia AU - Shahsavari, Fatemeh AU - Hezarkhani, Maliheh AU - Shafizadeh, Maryam AD - Dept. of Oral and Maxillofacial Pathology, Dental Branch of Tehran, Islamic Azad University, Tehran, Iran. Y1 - 2019 PY - 2019 VL - 20 IS - 1 SP - 10 EP - 15 KW - Angiogenesis KW - Pathologic KW - Giant cell Granuloma KW - CD34 KW - CD31 KW - Jaw DO - 10.30476/dentjods.2019.44557 N2 - Statement of the Problem: Considering the clinical differences between central giant cell granulomas (CGCGs) and peripheral giant cell granulomas (CGCGs) despite their same microscopic feature and possible role of angiogenesis in this issue, Purpose: The aim of the present study was to compare microvessel density (MVD) between CGCGs and PGCGs of the oral cavity using CD31 and CD34.Materials and Method: Immunohistochemical staining was performed on 18 PGCGs and 19 CGCGs using a monoclonal antibody against CD34 and CD31. MVD was assessed and compared between the lesions using T-test for statistical analysis. p < 0.05 was considered significant.Results: The expression levels of both CD34 and CD31 were significantly higher in CGCGs compared to PGCGs (p < 0.002 and p < 0.001, respectively). Significant differences in MVD assessed by both markers were observed between males and females in PGCGs (p < 0.05), but not CGCGs (p < 0.2).Conclusion: The combined evaluation of old- and newly-formed vessels by pan-endothelial cell markers showed differences between CGCGs and PGCGs, supporting the possible vascular-proliferative nature of the former. Whether this difference has a part in their diverse biologic behaviors and the role which pre-existent vessels play in comparison to neo-formed vasculature, requires further investigation. UR - https://dentjods.sums.ac.ir/article_44557.html L1 - https://dentjods.sums.ac.ir/article_44557_1e8000ffd31664de3d8cc736c912d378.pdf ER -