TY - JOUR ID - 46656 TI - Histomorphometric Effects of 2% Risedronate Gel on Calvarial Bone Defects in Rabbits JO - Journal of Dentistry JA - DENTJODS LA - en SN - 2345-6485 AU - Aghayan, Shabnam AU - Asghari, Ahmad AU - Mortazavi, Pejman AU - Marzoughi, Shirin AD - Dept. of Periodontology, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. AD - Dept. of Clinical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran. AD - Head of Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran. AD - Postgraduate Student of Pediatric Dentistry, Dental Research Center, Dept. of Pediatric Dentistry, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. Y1 - 2021 PY - 2021 VL - 22 IS - 1 SP - 14 EP - 20 KW - Bone Loss KW - Osteoclast KW - Rabbit KW - Risedronate DO - 10.30476/dentjods.2020.82926.1032 N2 - Statement of the Problem: Alveolar bone resorption due to periodontal disease is common and generally irreversible. It impairs mastication and causes esthetic problems for patients.Bisphosphonates are the most commonly used antiresorptive agents for bone diseases. Purpose: Considering the risk of bisphosphonate-related osteonecrosis of the jaw, this study aimed to assess the effect of 2% risedronate gel on calvarial bone defects in rabbits. Materials and Method: In this animal study, 8 mm critical size defect were created in the calvaria of 20 New Zealand white rabbits. In group 1 (n=10), 2% risedronate gel was applied into the right side defect while the left side defect remained empty and served as control. In group 2 (n=10), placebo gel was applied into the right side defect, while the left side defect remained empty and served as control. Five rabbits in each group were sacrificed at 1 and the remaining five at 2 months post-operatively and tissue samples were collected for histomorphometric analysis. Histomorphometric assessments included bone fill, degree of inflammation, number of osteoblasts, number of osteoclasts and foreign body reaction at the site. Data were statistically analysed using SPSS version 25 via the Dunn test and Kruskal-Wallis test. Results: No bone remodeling was noted in any group at 1 month. The risedronate group showed significantly higher bone fill than the other groups after 2 months (p = 0.016). At 2 months, the number of osteoblasts was significantly higher in the risedronate group (p < 0.05). The groups were not significantly different in terms of inflammation score at 1 (p = 0.31) or 2 (p =0.69) months. Foreign body reaction was not observed in any group at any time point. No osteoclast was detected in any group at any time point. Conclusion: Risedronate gel showed superior efficacy with regard to regeneration of rabbit calvarial bone defects compared to the placebo and control groups.  UR - https://dentjods.sums.ac.ir/article_46656.html L1 - https://dentjods.sums.ac.ir/article_46656_6322f3b5de2c142fa2c8be63bdb40fca.pdf ER -