TY - JOUR ID - 47140 TI - Evaluation of Salivary Level of Heat Shock Protein 70 in Patients with Chronic Periodontitis JO - Journal of Dentistry JA - DENTJODS LA - en SN - 2345-6485 AU - Motahari, Paria AU - Pourzare Mehrbani, Solmaz AU - Jabbarvand, Hamed AD - Dept. of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Dentist, Dept. of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. Y1 - 2021 PY - 2021 VL - 22 IS - 3 SP - 175 EP - 179 KW - Chronic periodontitis KW - HSP70 heat-shock proteins KW - Saliva DO - 10.30476/dentjods.2020.87080.1228 N2 - Statement of the Problem: Traditional clinical criteria are usually not sufficient to determine the sites of active periodontal disease, monitoring response to treatment, or measuring the susceptibility to future disease development. Past studies have shown that heat shock protein 70 (HSP70) are involved in the etiology of periodontal disease. Purpose: The aim of this study was to evaluate the level of HSP70 in saliva of patients with chronic periodontitis (CP). Materials and Method: In our case-control study, the saliva samples of 45 patients with CP and 45 age- and sex-matched healthy subjects were collected. Salivary HSP70 was measured by enzyme-linked immunosorbent assay method. The results were analyzed based on statistical tests. The software which used in this study was SPSS 16 and statistically significant difference was considered when p < 0.05. Results: In this study, the mean salivary HSP70 level was 2.81±0.61ng/ml in the patient group and 1.96±0.77ng/ml in the healthy group, with a significant difference (p < 0.05). Also, the results of spearman correlation analysis showed a positive correlation between salivary HSP 70 and clinical periodontal index. Conclusion: The results of this study showed that the salivary HSP70 level in patients with CP is higher than healthy subjects. As a result, salivary HSP70 can be considered as a marker in the pathogenesis of CP. UR - https://dentjods.sums.ac.ir/article_47140.html L1 - https://dentjods.sums.ac.ir/article_47140_6aeee0ac4d5f1e7790b5b741c9fa3aba.pdf ER -