Document Type: Case Report

Authors

1 Dept. of Oral and Maxillofacial Pathology, Dental School of Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Dept. of Periodontics, Dental School of Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Melanotic neuroectodermal tumor of infancy is a rare, rapidly growing, painless, pigmented neoplasm with neural crest derivation. It usually occurs during the first year of life and there is a prominent predilection for the maxilla. The purpose of the present report is to describe additional case of melanotic neuroectodermal tumor of infancy of maxilla in a 6-month-old infant male. The treatment included surgical excision with safe margins. No attempt was made for immediate grafting of the surgery site due to high proliferation rate of tissues and self-renewal during infancy. The facial growth was normal and the surgical cleft was tightly closed. Due to the rarity of tumor, essential knowledge on characteristics of this lesion would contribute to a proper diagnosis and benefit treatment planning.

Keywords

1. Angervall L, Enzinger FM. Extraskeletal neoplasm resembling Ewing's sarcoma. Cancer. 1975; 36: 240–251. [PubMed[Google Scholar]

2. Sinha DK, Jha NK, Yadav SK, Yadav J, Sinha R. Ewing's Sarcoma of Mandible: A Very Rare Disease and Review of Indian Literature. Indian J Surg Oncol. 2014; 5: 81–84. [PMC free article] [PubMed[Google Scholar]

3. Ko E, Brouns ER, Korones DN, Pochal WF, Philipone EM, Zegarelli DJ, et al. Primary Ewing sarcoma of the anterior mandible localized to the midline. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013; 115: e46–e50. [PubMed[Google Scholar]

4. Cho SI, Park YH, Cho JH, Ryoo BY, Yang SH, Youn SM, et al. Extraskeletal Ewing's sarcoma of the head and neck presenting as blindness. Korean J Intern Med. 2007; 22: 133–137. [PMC free article] [PubMed[Google Scholar]

5. Berk R, Heller A, Heller D, Schwartz S, Klein EA. Ewing's sarcoma of the mandible: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995; 79: 159–162. [PubMed[Google Scholar]

6. Mukherjee A, Ray JG, Bhattacharya S, Deb T. Ewing's sarcoma of mandible: A case report and review of Indian literature. Contemp Clin Dent. 2012; 3: 494–498. [PMC free article] [PubMed[Google Scholar]

7. Wood RE, Nortje CJ, Hesseling P, Grotepass F. Ewing's tumor of the jaw. Oral Surg Oral Med Oral Pathol. 1990; 69: 120–127. [PubMed[Google Scholar]

8. Wang CL, Yacobi R, Pharoah M, Thorner P. Ewing's sarcoma: metastatic tumor to the jaw. Oral Surg Oral Med Oral Pathol. 1991; 71: 597–602. [PubMed[Google Scholar]

9. Talesh KT, Motamedi MH, Jeihounian M. Ewing's sarcoma of the mandibular condyle: report of a case. J Oral Maxillofac Surg. 2003; 61: 1216–1219. [PubMed[Google Scholar]

10. Ng SH, Ko SF, Cheung YC, Wong HF, Jung SM. Extraskeletal Ewing's sarcoma of the parapharyngeal space. Br J Radiol. 2004; 77: 1046–1049. [PubMed[Google Scholar]

11. Sandhya K, Sangeetha K, Balan A, Girija K, Bose T. Extraskeletal Ewing’s Sarcoma of Floor of Mouth: A 1-year follow-up of the Rare Disease in a Rare Location. International Journal of Scientific Study. 2017; 4: 220–223. [Google Scholar]

12. Narula MK, Gupta N, Anand R, Kapoor S. Extraosseous Ewing's sarcoma / primitive neuroectodermal tumor of the sacral nerve plexus. Indian J Radiol Imaging. 2009; 19: 151–154. [PMC free article] [PubMed[Google Scholar]

13. Tarazona N, Navarro L, Cejalvo JM, Gambardella V, Pérez-Fidalgo JA, Sempere A, et al. Primary paraesophageal Ewing's sarcoma: an uncommon case report and literature review. Onco Targets Ther. 2015; 8: 1053–1059. [PMC free article] [PubMed[Google Scholar]

14. Berková A, Dundr P, Povýsil C, Melcákova S, Tvrdík D. A comparison of RT-PCR and FISH techniques in molecular diagnosis of Ewing's sarcoma in paraffin-embedded tissue. Cesk Patol. 2008; 44: 67–70. [PubMed[Google Scholar]

15. Machado I, Noguera R, Pellin A, Lopez-Guerrero JA, Piqueras M, Navarro S, et al. Molecular diagnosis of Ewing sarcoma family of tumors: a comparative analysis of 560cases with FISH and RT-PCR. Diagn Mol Pathol. 2009; 18: 189–199. [PubMed[Google Scholar]