@article { author = {PKS, Sasi and Varghese, Sheeja and S, Thanga and N, Jaga and G, Lambo}, title = {Association of IL-17A Polymorphism with Chronic Periodontitis in Type 1 Diabetes Patients}, journal = {Journal of Dentistry}, volume = {22}, number = {3}, pages = {180-186}, year = {2021}, publisher = {Shiraz University of Medical Sciences}, issn = {2345-6485}, eissn = {2345-6418}, doi = {10.30476/dentjods.2020.86990.1222}, abstract = {Statement of the Problem: The association of genetic polymorphisms with periodontitis has been studied extensively. The IL-17 is a group of cytokines which comprises six different molecules (IL-17A, B, C, D, E & F). Among these IL-17A & F are the most commonly understood cytokine which plays a critical role in inflammatory diseases and periodontal inflammation. Purpose: To evaluate whether Interleukin -17A gene polymorphism is associated with increased risk of chronic periodontitis in type 1 diabetes patients. Materials and Method: The quantitative case- control study was carried out in 60 subjects and consists of 4 groups which included, Group A: 15 Type 1 diabetes patients (T1DM) with chronic periodontitis (CP), Group B: 15 T1DM patients without CP, Group C: 15 Non-diabetic patients with CP, Group D: 15 Non-diabetic patients without CP. Blood samples were drawn from the subjects and analyzed for IL-17A polymorphism by using the polymerase chain reaction-restriction fragment length polymorphism method. Results: There was no statistical significant difference seen in the genotype distribution among CP patients with or without T1DM and healthy controls. Odds ratio and p value indicated that increased risks for CP were associated with IL-17A allele (G) in patients with T1DM. This allele was correlated with worse clinical parameters of CP in T1DM patients. Conclusion: The present study revealed that IL-17A (rs2275913) polymorphism was not associated with increased risk for CP in T1DM patients.  }, keywords = {IL-17A,Polymorphisms Type 1 Diabetes,Chronic periodontitis,ethnicity}, url = {https://dentjods.sums.ac.ir/article_47141.html}, eprint = {https://dentjods.sums.ac.ir/article_47141_9ebba021d457fc36530e98b2deb42068.pdf} }