%0 Journal Article %T Association of IL-17A Polymorphism with Chronic Periodontitis in Type 1 Diabetes Patients %J Journal of Dentistry %I Shiraz University of Medical Sciences %Z 2345-6485 %A PKS, Sasi Kumar %A Varghese, Sheeja %A S, Thanga Kumaran %A N, Jaga Desaan %A G, Lambo Daran %D 2021 %\ 09/01/2021 %V 22 %N 3 %P 180-186 %! Association of IL-17A Polymorphism with Chronic Periodontitis in Type 1 Diabetes Patients %K IL-17A %K Polymorphisms Type 1 Diabetes %K Chronic periodontitis %K ethnicity %R 10.30476/dentjods.2020.86990.1222 %X Statement of the Problem: The association of genetic polymorphisms with periodontitis has been studied extensively. The IL-17 is a group of cytokines which comprises six different molecules (IL-17A, B, C, D, E & F). Among these IL-17A & F are the most commonly understood cytokine which plays a critical role in inflammatory diseases and periodontal inflammation. Purpose: To evaluate whether Interleukin -17A gene polymorphism is associated with increased risk of chronic periodontitis in type 1 diabetes patients. Materials and Method: The quantitative case- control study was carried out in 60 subjects and consists of 4 groups which included, Group A: 15 Type 1 diabetes patients (T1DM) with chronic periodontitis (CP), Group B: 15 T1DM patients without CP, Group C: 15 Non-diabetic patients with CP, Group D: 15 Non-diabetic patients without CP. Blood samples were drawn from the subjects and analyzed for IL-17A polymorphism by using the polymerase chain reaction-restriction fragment length polymorphism method. Results: There was no statistical significant difference seen in the genotype distribution among CP patients with or without T1DM and healthy controls. Odds ratio and p value indicated that increased risks for CP were associated with IL-17A allele (G) in patients with T1DM. This allele was correlated with worse clinical parameters of CP in T1DM patients. Conclusion: The present study revealed that IL-17A (rs2275913) polymorphism was not associated with increased risk for CP in T1DM patients.   %U https://dentjods.sums.ac.ir/article_47141_9ebba021d457fc36530e98b2deb42068.pdf