Document Type: Review Article


Dept. of Oral Medicine, School of Dentistry, Mashhad University of Medical Science, Mashhad, Iran


Despite the absence of any signs of infection in the oral cavity, all dentists and specialists should take prevention of infection and conditions leading to high risk infection into account. Antibiotic prophylaxis could inhibit or lessen the rate of such occurrences.The aim of this review was to describe all risks and side effects of missing prophylaxis and also to mention mechanisms and conditions which precipitate these risks. Hence, we could categorize and exactly define these risks and patients at risk and recommend the best approaches to preventing the risks, selecting antibiotic type, appropriate time for indication, duration of administration, and also all changes based on specific cases.Key words: Antibiotic, Infective endocarditis, Dental management, Prophylactic antibiotic