An abnormally small oral orifice is defined as microstomia which is caused by various factors like burning, scleroderma, etc. This disorder is difficult to treat due to the reduced oral opening. In particular, fabrication of removable prostheses is further complicated by tongue rigidity and the constant adjustment required to accommodate the changing periphery; however, successful treatment is possible through specific measures. In this article, a 41-year-old woman living in Baghmalek, Khoozestan was referred to the Prosthodontic department of Jondishapoor University in Ahvaz, southern Iran. She was suffering from microstomia and poor manual ability caused by scleroderma. Initial impression was prepared for her, using Silicon impression material by applying fingers pressure. The final impression was prepared using a two section tray so that the larger part covered one third of the smaller one and both could be attached by compressable button. Then the occlusal relation was established using occlusal rims connected to the two section parcels. Two part parcel prostheses connected with attachments were made for the lower and upper jaws, respectively. The patient was followed up for six months.Conclusion: In order to overcome the above-mentioned problems, the new method of removable prosthesis enjoys the advantage of sufficient precision as well as ease of use by the patient. For further evaluation, diagnosis and proper treatment plan are reportedKey words: Microstomia, Sectional impression trays, Sectional removable dentures, Scleroderma