Statement of Problems: Job burnout is a result of frequent and constant physical and mental stress in a long time. Dentistry is one of the most stressful jobs in the field of medicine. These stressful factors make dentists prone to burnout and psychological disorders such as depression and anxiety.Purpose: The aim of this study was to measure the relationship between demographic and personality characteristics and job satisfaction and burnout in dentists.Materials and Method: In this simple filter sampling study, 30 dentists as faculty members of the dental school of Shiraz University filled in questionnaires about job satisfaction, job burnout and general health. Statistical methods such as Pierson Correlation Coefficient, Multivariate Analysis and Chi-Square test were used.Results: In this study, 12 males (40%) and 18 females (60%) were involved. The mean occupation year for females were more than that of males. Meanwhile, men practice more hours a day. There was no significant difference between males and females regarding general heath and job satisfaction. Dental chair side hours and years of occupation had no effect on general health and job satisfaction. The results showed that NEO 5-personality factors, sex, occupation years and age did not have any meaningful effect on job burnout, but this study could predict 29% of the job dissatisfaction ( p =45% ; F=06% ; R square=29%; R=54%).Conclusion: In this study, age, sex and occupation years did not have any effect on the job burnout, but with the increase in the volume of the sample, it would be meaningful. This study was conducted only on the faculty members; which makes it different from other studies.Key words: job burnout, Dentists, Demographic and personality character