Statement of Problem: Odontogenic cysts (OC) are relatively common lesions that can behave aggressively and attain large sizes.                                       Purpose: This study has been conducted to evaluate the prevalence of OCs and their clinical features in three centers in Shiraz which receive most of the oral biopsy specimen in Fars province.Materials and Methods: In this retrospective study, the histopathologic reports from the archives of the department of pathology of Shiraz Dental School, Khalili and Namazi Hospitals pertaining to a 10 year interval (1375-1385) were reviewed. All odontogenic cysts were listed and their clinical features including  sex, age and location were registered and classified according to the latest classification of  World Health Organization (WHO) in OCs the results were than descriptively  analyzed.       Results: Among a total of 110,000 files, 179 were retrieved as OCs after excluding 45 cases of OCs that were non-specifically reported as infected odontogenic cyst. The remainder consisted of 44 cases of radicular syst (32.83%), 42 cases of Dentigerous cyst (31.34%) and 35 cases of Odontogenic keratocyst (26.12%), respectively. OCs was more prevalent in male gender, the posterior mandible and 2nd decade of life.          Conclusion: The most frequent OCs, in the studying population were radicular cyst and dentigerous cyst, respectively.Key words: Odontogenic cyst, Radicular cyst, Odontogenic Keratocyst, Dentigerous cyst