Document Type: Original Article


1 Dept. of Oral Medicine, School of Dentistry, Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Dept. of ENT, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

3 Specialist in Oral Medicine, Mashhad, Iran


Statement of Problem: Most of solitary head and neck lymphadenopathic patients, due to similar symptoms and histories, are evaluated by special paraclinical tests and even unneccessary biopsies.Purpose: The aim of this study was to investigate the effect of high does of oral amoxicilin on solitary head and neck lymphadenopathies during a limited period of time.Materials and Method: This descriptive-interventional study was conducted in census form. The experimental populations were solitary head and neck lymphadenopathic patients suffering for a period of less than two months with the lymph node size of 1.5 cm or more. Patients with weight of more than 27 kg, were treated by 2 gr of amoxicilin every six hours for three days and received the drug daily as follow up. For individuals weighted less than 27 kg, the drug was prescribed as 100 mg / kg daily divided in four equal doses. At the end of the third day to the end of the seventh day from the treatment onset, amoxicilin offering was continued by a lower dose of one gram every six hours. Data obtained on the lymph node size were analyzed using Mann-Whitney test ( p < 0/05).Results: Seventeen patients developed complete improvement, but eight did not respond to this treatment regimen. The failure was found to be due to the existence of tumoral tissue, infection or treatment resistance, and lymphocytic infiltration without any particular etiology in two, two, and remaining four cases, respectively.Conclusion: According to the results of this study, it is concluded that prescribing high dose of amoxicillin, for a limited period of time, for all questionable solitary head and neck lymphadenopathic patients, considering the previous descriptive conditions, would be a useful diagnostic-treating approach.Key words: Lymphatic diseases, Dose, Oral, Amoxicillin