Statement of the Problem: The use of miniscrew as an absolute anchorage device in clinical orthodontics is growing increasingly. Many attempts have been made to reduce the size, to improve the design, and to increase the stability of miniscrew.Purpose: The purpose of this study was to determine the effects of different thread shapes and force directions of orthodontic miniscrew on stress distribution in the supporting bone structure.Materials and Method: A three-dimensional finite element analysis was used. A 200-cN force in three angles (0°, 45°, and 90°) was applied on the head of the miniscrew. The stress distribution between twelve thread shapes was investigated as categorized in four main groups; buttress, reverse buttress, square, and V-shape.Results: Stress distribution was not significantly different among different thread shapes. The maximum amount of bone stress at force angles 0°, 45°, and 90° were 38.90, 30.57 and 6.62 MPa, respectively. Analyzing the von Mises stress values showed that in all models, the maximum stress was concentrated on the lowest diameter of the shank, especially the part that was in the soft tissue and cervical cortical bone regions.Conclusion: There was no relation between thread shapes and von Mises stress distribution in the bone; however, different force angles could affect the von Mises stress in the bone and miniscrew.