Statement of the Problem: Mechanical properties of interim restorations are considered as important factors specially when selecting materials for long-term application or for patients with para-functional habits. Flexural strength is one of the most important components of these restorations.Purpose: The purpose of this study was to compare the flexural strength of five interim restorative materials.Materials and Method: Fifty identical samples sized 25×2×2-mm were made from five interim materials (TempSpan; Protemp 4, Unifast III, Trim, and Revotek LC) according to ADA specification #27. The specimens were stored in artificial saliva for 2 weeks and then thermocycled for 2500 cycles (5-55˚C). A standard three-point bending test was conducted on the specimens with a universal testing machine at a crosshead speed of 0.75mm/min. Data were analyzed by using one-way ANOVA and Tamhane’s post-hoc tests to measure the flexural strength of temporary materials.Results: One of the bis-acryl resins (TempSpan) showed the highest, and the light polymerized resin (Revotek LC) showed the lowest flexural strength. The mean values of flexural strength (MPa) for the examined materials were as follow: TempSpan=120.00, Protemp 4=113.00, Unifast III=64.20, Trim= 63.73 and Revotek LC=47.16. There were significant differences between all materials except Trim and Unifast III which did not show any statistical significant difference.Conclusion: Bis-acryl resins were statistically superior to traditional methacrylate and light-cured resins. Therefore, application of bis-acryl resins should be deliberated in patients with heavy occlusion and in cases that need long-term use of interim restorations.