Comparing Vitamin D Serum Levels in Patients with Oral Lichen Planus and Healthy Subjects

Bahramian, Ayla; Bahramian, Maria; Mehdipour, Masoumeh; Falsafi, Parisa; Khodadadi, Saeed; Dabaghi Tabriz, Fatemeh; Deljavanghodrati, Mina

doi:10.30476/dentjods.2018.41814

Comparing Vitamin D Serum Levels in Patients with Oral Lichen Planus and Healthy Subjects

Document Type : Original Article

Authors

Ayla Bahramian ¹

Maria Bahramian ²

Masoumeh Mehdipour ³

Parisa Falsafi ¹

Saeed Khodadadi ⁴

Fatemeh Dabaghi Tabriz ⁵

Mina Deljavanghodrati ⁶

¹ Dept. of Oral Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

² Postgraduate Student, Dept. of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran

³ Dept. of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

⁴ Dentist, Shiraz, Iran.

⁵ Dept. of Operative Dentistry, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

⁶ Medical Student, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

https://doi.org/10.30476/dentjods.2018.41814

Abstract

Statement of the Problem: Lichen planus disease is a chronic inflammatory lesion without a known etiology. Recent studies have indicated the role of vitamin D on immune system and proposed its anti-inflammatory effects.Purpose: This study aimed to compare vitamin D serum levels in patients with oral lichen planus and healthy subjects.Materials and Method: In this case‒control study, 18 patients suffering from oral lichen planus referred to the Department of Oral Medicine, Tabriz Faculty of Dentistry were chosen as the case group and 18 healthy people were chosen as the control group. A 5-mL blood sample was taken from all subjects and the subjects’ vitamin D serum levels were assessed with a vitamin D total (25-hydroxy vitamin D) kit by employing the electrochemiluminescence technique. The results were analyzed and compared by using SPSS17 statistic software. p< 0.05 was considered statistically significant. Results: The mean vitamin D level in serum of patients with oral lichen planus was 30.7±20.38ng/ml and in healthy subjects was 36.45± 15.33ng/ml, the difference was not statistically significant (p= 0.346). Conclusion: The difference between the level of vitamin D in the serum of patients suffering from oral lichen planus and healthy individuals was not significant.Key Words Lichen Planus; Oral; Vitamin D; Serum;