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The Association between Burning Mouth Syndrome and Level of Thyroid Hormones in Hashimotos Thyroiditis in Public Hospitals in Shiraz, 2016

Document Type : Original Article

Authors

1 Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Azad Islamic University, Shiraz, Iran.

2 Shiraz Endocrinology and Metabolism Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.

3 Undergraduate Student, Student Research Committee, School of Dentistry, Shiraz University of Medical Science, Shiraz, Iran.

4 Postgraduate Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

5 Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical science, Shiraz, Iran.

Abstract

Statement of the Problem: Burning sensation in Hashimoto patient’s oral cavity is an unknown prevalent problem.Purpose: This study aimed to evaluate the prevalence and intensity of burning mouth syndrome (BMS) in patients suffering from Hashimoto’s thyroiditis in all public hospitals in Shiraz, 2016.Materials and Method: A total of 153 patients with Hashimoto’s thyroiditis were selected based on simple random sampling. The initial level of thyroid stimulating hormone (TSH), Anti-TPO (thyroperoxidase), Anti-TG (thyroglobulin), Free T3 (triiodothyronine) and Free T4 (thyroxine) serum as the indices of Hashimoto’s thyroiditis was assessed. The BMS intensity was measured according to each patient's verbal or nonverbal expression about the pain experience based on visual analog scale (VAS).Results: Based on the clinical evaluation and interview, only 19out of 153 cases (12%) reported BMS. The mean BMS was 3 based on VAS. Statistically significant association was detected between the level of TSH (p= 0.0001), Anti-TPO (p= 0.035), Anti-TG (p= 0.0001), Free T3 (p= 0.0001), Free T4 (p= 0.0001) indices in patients with BMS. Significant association was also observed between the level of Anti-TPO (p= 0.0001), Anti-TG (p= 0.0001), Free T3 (p= 0.0001) and TSH (p= 0.0001) indices and BMS intensity. However, no significant association was found between the BMS severity and Free T4 (p= 0.056).Conclusion: The level of TSH, Anti-TPO, and Anti-TG, Free T3, and TSH indices of Hashimoto’s patients were associated with the presence and severity of BSM. However, Free T4 level was only associated with the presence of BMS and not the intensity.

Keywords

References
1. Pyzik A, Grywalska E, Matyjaszek-Matuszek B, Roliński J. Immune disorders in Hashimoto's thyroiditis: what do we know so far? J Immunol Res. 2015; 2015: 979167. [PMC free article] [PubMed] [Google Scholar]
2. Saki F, Dabbaghmanesh MH, Ghaemi SZ, Forouhari S, Omrani GR, Bakhshayeshkaram M. Thyroid autoimmunity in pregnancy and its influences on maternal and fetal outcome in Iran (a prospective study) Endocr Res. 2015; 40: 139–145. [PubMed] [Google Scholar]
3. Rostamzadeh D, Dabbaghmanesh MH, Shabani M, Hosseini A, Amirghofran Z. Expression Profile of Human Fc Receptor-Like 1, 2, and 4Molecules in Peripheral Blood Mononuclear Cells of Patients with Hashimoto's Thyroiditis and Graves' Disease. Horm Metab Res. 2015; 47: 693–698. [PubMed] [Google Scholar]
4. Wirtschafter A, Schmidt R, Rosen D, Kundu N, Santoro M, Fusco A, et al. Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto's thyroiditis. Laryngoscope. 1997; 107: 95–100. [PubMed] [Google Scholar]
5. Karimi F, Kalantarhormozi MR, Dabbaghmanesh MH, Ranjbar Omrani G. Thyroid disorders and the prevalence of antithyroid antibodies in Shiraz population. Arch Iran Med. 2014; 17: 347–351. [PubMed] [Google Scholar]
6. Grani G, Carbotta G, Nesca A, D'Alessandri M, Vitale M, Del Sordo M, et al. A comprehensive score to diagnose Hashimoto's thyroiditis: a proposal. Endocrine. 2015; 49: 361–365. [PubMed] [Google Scholar]
7. Özen S, Berk Ö, Şimşek DG, Darcan S. Clinical course of Hashimoto's thyroiditis and effects of levothyroxine therapy on the clinical course of the disease in children and adolescents. J Clin Res Pediatr Endocrinol. 2011; 3: 192–197. [PMC free article] [PubMed] [Google Scholar]
8. Talattof Z, Azad A. An Evaluation of Knowledge, Attitude and Practice of Adverse Drug Reaction Reporting in Dental Practice. Pakistan Journal of Nutrition. 2015; 14: 712–715. [Google Scholar]
9. Crow HC, Gonzalez Y. Burning Mouth Syndrome. Oral and maxillofacial surgery clinics of North America. 2013; 25: 67–76. [PubMed] [Google Scholar]
10. Minguez-Sanz MP, Salort-Llorca C, Silvestre-Donat FJ. Etiology of burning mouth syndrome: a review and update. Med Oral Patol Oral Cir Bucal. 2011; 16: 144–148. [PubMed] [Google Scholar]
11. Savage NW, Boras VV, Barker K. Burning mouth syndrome: clinical presentation, diagnosis and treatment. Australas J Dermatol. 2006; 47: 77–81. [PubMed] [Google Scholar]
12. Salort-Llorca C, Mínguez-Serra MP, Silvestre FJ. Drug-induced burning mouth syndrome: a new etiologicaldiagnosis. Med Oral Patol Oral Cir Bucal. 2008; 13: E167–E170. [PubMed] [Google Scholar]
13. Baharvand M, Rafieian N, Bakhtiari S. Review article of Burning mouth syndrome (BMS) Shahid Beheshti University Dental Journal. 2010; 28: 172–179. [Google Scholar]
14. Femiano F, Lanza A, Buonaiuto C, Gombos F, Nunziata M, Cuccurullo L, et al. Burning mouth syndrome and burning mouth in hypothyroidism: proposal for a diagnostic and therapeutic protocol. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 105: e22–e27. [PubMed] [Google Scholar]
15. Femiano F, Gombos F, Esposito V, Nunziata M, Scully C. Burning mouth syndrome (BMS): evaluation of thyroid and taste. Med Oral Patol Oral Cir Bucal. 2006; 11: E22–E25. [PubMed] [Google Scholar]
16. Momota Y, Takano H, Kani K, Matsumoto F, Motegi K, Aota K, et al. Frequency analysis of heart rate variability: a useful assessmenttool of linearly polarized near-infrared irradiation to stellateganglion area for burning mouth syndrome. Pain Med. 2013; 14: 351–357. [PubMed] [Google Scholar]
17. Lamey PJ, Freeman R, Eddie SA, Pankhurst C, Rees T. Vulnerability and presenting symptoms in burning mouth syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 99: 48–54. [PubMed] [Google Scholar]
18. Suarez P, Clark GT. Burning mouth syndrome: an update on diagnosis and treatment methods. J Calif Dent Assoc. 2006; 34: 611–622. [PubMed] [Google Scholar]
19. Femiano F, Gombos F, Esposito V, Nunziata M, Scully C. Burning mouth syndrome (BMS): evaluation of thyroid and taste. Med Oral Patol Oral Cir Bucal. 2006; 11: E22–E25. [PubMed] [Google Scholar]
20. Sardella A, Gualerzi A, Lodi G, Sforza C, Carrassi A, Donetti E. Morphological evaluation of tongue mucosa in burning mouth syndrome. Arch Oral Biol. 2012; 57: 94–101. [PubMed] [Google Scholar]
21. Scardina GA, Ruggieri A, Messina P. Oral microcirculation observed in vivo by videocapillaroscopy: a review. J Oral Sci. 2009; 51: 1–10. [PubMed] [Google Scholar]
22. Pekiner FN, Demirel GY, Gümrü B, Ozbayrak S. Serum cytokine and T regulatory cell levels in patients with burning mouth syndrome. J Oral Pathol Med. 2008; 37: 528–534. [PubMed] [Google Scholar]
23. Lin HP, Wang YP, Chen HM, Kuo YS, Lang MJ, Sun A. Significant association of hematinic deficiencies and high bloodhomocysteine levels with burning mouth syndrome. J Formos Med Assoc. 2013; 112: 319–325. [PubMed] [Google Scholar]
24. Kato Y, Sato T, Katagiri A, Umezaki Y, Takenoshita M, Yoshikawa T, et al. Milnacipran dose-effect study in patients with burning mouthsyndrome. Clin Neuropharmacol. 2011; 34: 166–169. [PubMed] [Google Scholar]
25. Moore PA, Guggenheimer J, Orchard T. Burning mouth syndrome and peripheral neuropathy in patientswith type 1 diabetes mellitus. J Diabetes Complications. 2007; 21: 397–402. [PubMed] [Google Scholar]
Journal of Dentistry
Volume 20, Issue 1 - Serial Number 1
March 2019
Pages 42-47
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