Papillary Thyroid Carcinoma Coexistent with Oral Squamous Cell Carcinoma: A Case Report and Review of Literature

Jaafari Ashkavandi, Zohreh; Keshvari, Haleh; Danesteh, Hossein

doi:10.30476/dentjods.2019.44901

Papillary Thyroid Carcinoma Coexistent with Oral Squamous Cell Carcinoma: A Case Report and Review of Literature

Document Type : Case Report

Authors

Zohreh Jaafari Ashkavandi ¹

Haleh Keshvari ²

Hossein Danesteh ³

¹ Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

² Postgraduate Student, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

³ Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

https://doi.org/10.30476/dentjods.2019.44901

Abstract

Multiple primary tumors may develop in patients with head and neck squamous cell carcinoma. The coincidence of head and neck squamous cell carcinoma with papillary thyroid carcinoma is a rare finding. This study reports a case of papillary thyroid carcinoma, which was incidentally detected during the microscopic examination of lymph nodes of a patient diagnosed as gingival squamous cell carcinoma. A review of literature is also presented.

Keywords

Squamous cell carcinoma ● Thyroid carcinoma ● Gingiva ● Lymph node ● Metastasis

1. Kapoor C, Vaidya S, Wadhwan V, Malik S. Lymph node metastasis: A bearing on prognosis in squamous cell carcinoma. Indian J Cancer. 2015; 52: 417–424. [PubMed] [Google Scholar]

2. Kim JW, Lee CY, Oh SM, Yang BE, Kim JY, Song YJ, et al. Gingival Squamous Carcinoma with Metastatic Lymph Node Involvement of Papillary Thyroid Carcinoma. J Korean Assoc Maxillofac Plast Reconstr Surg. 2012; 34: 276–279. [Google Scholar]

3. Jones AS, Morar P, Phillips DE, Field JK, Husband D, Helliwell TR. Second primary tumors in patients with head and necksquamous cell carcinoma. Cancer. 1995; 75: 1343–1353. [PubMed] [Google Scholar]

4. Pitman KT, Johnson JT, Myers EN. Papillary thyroid carcinoma associated with squamous cell carcinoma of the head and neck: significance and treatment. Am J Otolaryngol. 1996; 17: 190–196. [PubMed] [Google Scholar]

5. Ansari-Lari MA, Westra WH. The prevalence and significance of clinically unsuspectedneoplasms in cervical lymph nodes. Head Neck. 2003; 25: 841–847. [PubMed] [Google Scholar]

6. Clark RL, Hickey RC, Butler JJ, Ibanez ML, Ballantyne AJ. Thyroid cancer discovered incidentally during treatment of an unrelated head and neck cancer: review of 16 cases. Ann Surg. 1966; 163: 665–671. [PMC free article] [PubMed] [Google Scholar]

7. Ashraf MJ, Alavi MS, Azarpira N, Khademi B. Simultaneous laryngeal squamous cell carcinoma and papillary thyroid carcinoma. Middle East Journal of Cancer. 2011; 2: 87–90. [Google Scholar]

8. Bishen KA, Singh A. A case of dual malignancy: Presenting the necessity for extensive sampling for pathologic examination. J Oral Maxillofac Pathol. 2011; 15: 306–310. [PMC free article] [PubMed] [Google Scholar]

9. Verma RK, Tripathi N, Aggarwal P, Panda NK. Metastatic papillary carcinoma thyroid co-existing with oral cavity squamous cell carcinoma: A case report and review of literature. Egyptian Journal of Ear, Nose, Throat and Allied Sciences. 2014; 15:125–128. [Google Scholar]

10. León X, Sancho FJ, García J, Sañudo JR, Orús C, Quer M. Incidence and significance of clinically unsuspected thyroidtissue in lymph nodes found during neck dissection in head and neck carcinoma patients. Laryngoscope. 2005; 115: 470–474. [PubMed] [Google Scholar]

11. López-Escámez JA, López-Nevot A, Moreno-García MI, Gámiz MJ, Salinero J. Cervical metastasis of occult papillary thyroid carcinoma associated with epidermoid carcinoma of the larynx. ORL J Otorhinolaryngol Relat Spec. 1999; 61: 224–226. [PubMed] [Google Scholar]

12. Butler JJ, Tulinius H, Ibanez ML, Ballantyne AJ, Clark RL. Significance of thyroid tissue in lymph nodes associated with carcinoma of the head, neck or lung. Cancer. 1967; 20: 103–112. [PubMed] [Google Scholar]

13. Perie S, Torti F, Lefevre M, Chabbert-Buffet N, Jafari A, Lacau St Guily J. Incidental cervical metastases from thyroid carcinoma during neck dissection. European Annals of Otorhinolaryngology, Head and Neck diseases. 2016; 133: 383–386. [PubMed] [Google Scholar]

14. Vassilopoulou-Sellin R, Weber RS. Metastatic thyroid cancer as an incidental finding during neck dissection: significance and management. Head Neck. 1992; 14: 459– 463. [PubMed] [Google Scholar]

15. Resta L, Piscitelli D, Fiore MG, Di Nicola V, Fiorella ML, Altavilla A, et al. Incidental metastases of well-differentiated thyroid carcinoma in lymph nodes of patients with squamous cell head and neckcancer: eight cases with a review of the literature. Eur Arch Otorhinolaryngol. 2004; 261: 473–478. [PubMed] [Google Scholar]

16. Sheahan P, Hafidh M, Toner M, Timon C. Unexpected findings in neck dissection for squamous cellcarcinoma: incidence and implications. Head Neck. 2005; 27: 28–35. [PubMed] [Google Scholar]

17. Fliegelman LJ, Genden EM, Brandwein M, Mechanick J, Urken ML. Significance and management of thyroid lesions in lymph nodesas an incidental finding during neck dissection. Head Neck. 2001; 23: 885–891. [PubMed] [Google Scholar]

18. Altumbabic H, Salkic A. Incidental metastasis of papillary thyroid carcinoma in lymph nodes of patient with squamous cell carcinoma of the oral cavity: a case report. Acta Med Sal. 2010;32:104–106. [Google Scholar]