Journal of Dentistry

Evaluation of Salivary Level of Heat Shock Protein 70 in Patients with Chronic Periodontitis

Document Type : Original Article

Authors

Paria Motahari 1
Solmaz Pourzare Mehrbani 1
Hamed Jabbarvand 2

1 Dept. of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

2 Dentist, Dept. of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

https://doi.org/10.30476/dentjods.2020.87080.1228
Abstract
Statement of the Problem: Traditional clinical criteria are usually not sufficient to determine the sites of active periodontal disease, monitoring response to treatment, or measuring the susceptibility to future disease development. Past studies have shown that heat shock protein 70 (HSP70) are involved in the etiology of periodontal disease.
Purpose: The aim of this study was to evaluate the level of HSP70 in saliva of patients with chronic periodontitis (CP).
Materials and Method: In our case-control study, the saliva samples of 45 patients with CP and 45 age- and sex-matched healthy subjects were collected. Salivary HSP70 was measured by enzyme-linked immunosorbent assay method. The results were analyzed based on statistical tests. The software which used in this study was SPSS 16 and statistically significant difference was considered when p < 0.05.
Results: In this study, the mean salivary HSP70 level was 2.81±0.61ng/ml in the patient group and 1.96±0.77ng/ml in the healthy group, with a significant difference (p < 0.05). Also, the results of spearman correlation analysis showed a positive correlation between salivary HSP 70 and clinical periodontal index.
Conclusion: The results of this study showed that the salivary HSP70 level in patients with CP is higher than healthy subjects. As a result, salivary HSP70 can be considered as a marker in the pathogenesis of CP.

Keywords

Chronic periodontitis
HSP70 Heat-Shock Proteins
Saliva
Journal of Dentistry
Volume 22, Issue 3 - Serial Number 72
September 2021
Pages 175-179

  • Receive Date 04 July 2020
  • Revise Date 02 September 2020
  • Accept Date 05 October 2020
  • First Publish Date 22 December 2020
  • Publish Date 01 September 2021

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