Journal of Dentistry

Association of IL-17A Polymorphism with Chronic Periodontitis in Type 1 Diabetes Patients

Document Type : Original Article

Authors

Sasi Kumar PKS 1
Sheeja Varghese 2
Thanga Kumaran S 3
Jaga Desaan N 4
Lambo Daran G 5

1 Dept. of Periodontics, JKKN Dental College and Hospital, Tamilnadu DrMGR Medical University, Chennai.

2 Dean & HOD, Dept. of Periodontics, Saveetha Dental College and Hospital, Chennai, Tamilnadu, India.

3 Dept. of Periodontics, JKKN Dental College and Hospital.

4 Dept. of Prosthodontics, JKKN Dental College and Hospital.

5 Dept. of Prosthodontics. Meenakshiammal Dental College

https://doi.org/10.30476/dentjods.2020.86990.1222
Abstract
Statement of the Problem: The association of genetic polymorphisms with periodontitis has been studied extensively. The IL-17 is a group of cytokines which comprises six different molecules (IL-17A, B, C, D, E & F). Among these IL-17A & F are the most commonly understood cytokine which plays a critical role in inflammatory diseases and periodontal inflammation.
Purpose: To evaluate whether Interleukin -17A gene polymorphism is associated with increased risk of chronic periodontitis in type 1 diabetes patients.
Materials and Method: The quantitative case- control study was carried out in 60 subjects and consists of 4 groups which included, Group A: 15 Type 1 diabetes patients (T1DM) with chronic periodontitis (CP), Group B: 15 T1DM patients without CP, Group C: 15 Non-diabetic patients with CP, Group D: 15 Non-diabetic patients without CP. Blood samples were drawn from the subjects and analyzed for IL-17A polymorphism by using the polymerase chain reaction-restriction fragment length polymorphism method.
Results: There was no statistical significant difference seen in the genotype distribution among CP patients with or without T1DM and healthy controls. Odds ratio and p value indicated that increased risks for CP were associated with IL-17A allele (G) in patients with T1DM. This allele was correlated with worse clinical parameters of CP in T1DM patients.
Conclusion: The present study revealed that IL-17A (rs2275913) polymorphism was not associated with increased risk for CP in T1DM patients.  

Keywords

IL-17A
Polymorphisms Type 1 Diabetes
Chronic Periodontitis
Ethnicity
Journal of Dentistry
Volume 22, Issue 3 - Serial Number 72
September 2021
Pages 180-186

  • Receive Date 04 July 2020
  • Revise Date 02 September 2020
  • Accept Date 14 October 2020
  • First Publish Date 22 December 2020
  • Publish Date 01 September 2021

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