Document Type : Case Report
Authors
1 Dept. of Periodontology, Pravara Institute of Medical Sciences, Rural Dental College Loni (Maharashtra) India.
2 Dept. of Oral Pathology and Microbiology, Pravara Institute of Medical Sciences, Rural Dental College Loni (Maharashtra) India.
Abstract
Spindle cell hemangioma (SCH), formerly called “spindle cell hemangioendothelioma”, is a rare benign histological variant of hemangioma characterized by the presence of two contrast zones, the first zone exhibits large dilated cavernous space with slit-like vascular spaces may show clear endothelial vacuoles resembling fat cells. SCH is often considered as pseudosarcomatous entity; it imposes a diagnostic challenge for oral pathologists due to its resemblance with Kaposi sarcoma. A total of 13 cases of SCH have been reported in the head and neck region to date and only 6 cases have been reported inside the oral cavity. We present a rare case of SCH located on the hard palate, which imitated Kaposi's sarcoma on histopathological examination. The expressions of various markers including EGR, CD 31, and HHV 8 yielded the final diagnosis of SCH. The markers EGR and HHV 8 have never been used in intraoral SCH before to the best of our knowledge; hence, the present report highlights the use of immunohistochemistry for the diagnosis of SCH.
Highlights
Amit Mani (Google Scholar)
Manas Bajpai (Google Scholar)
Keywords
- Fletcher CD, Beham A, Schmid C. Spindle cell haemangioendothelioma: A clinicopathological and immune histochemical study indicative of a non‑neoplastic lesion. Histopathology. 1991; 18: 291‑301.
- Savithri V, Suresh R, Janardhanan M, Aravind T. Spindle cell haemangioma: Report of a rare entity. J Oral Maxillofac Pathol. 2022; 26: 424.
- Murakami K, Yamamoto K, Sugiura T, Kirita T. Spindle cell hemangioma in the mucosa of the upper lip: a case report and review of the literature. Case Rep Dent. 2018; 2018: 1370701. doi: 10.1155/2018/1370701.
- Weiss SW, Enzinger FM. Spindle cell hemangioendothelioma: A low-grade angiosarcoma resembling a cavernous hemangioma and Kaposi's sarcoma. Am J Surg Pathol. 1986; 10: 521-530.
- Ide F, Obara K, Enatsu K, Mishima K, Saito I. Rare vascular proliferations of the oral mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2004; 97: 75‑78.
- Lade H, Gupta N, Singh PP, Dev G. Spindle‑cell hemangioendothelioma of the posterior pharyngeal wall. Ear Nose Throat J. 2005; 84: 362‑365.
- Perkins P, Weiss SW. Spindle cell hemangioendothelioma: An analysis of 78 cases with reassessment of its pathogenesis and biologic behavior. Am J Surg Pathol. 1996; 20: 1196-1204.
- Wang L, Gao T, Wang G. Expression of Prox1, D2‑40, and WT1 in spindle cell hemangioma. J Cutan Pathol. 2014; 41: 447‑450.
- Chavva S, Priya MH, Garlapati K, Reddy GS, Gannepalli A. Rare case of spindle cell haemangioma. J Clin Diagn Res. 2015; 9: ZD19‑ZD21.
- French KE, Felstead AM, Haacke N, Theaker J, Brennan PA, Colbert SD. Spindle cell haemangioma of the tongue. J Cutan Pathol. 2016; 43: 1025‑1027.
- Bajpai M, Pardhe N. Report of a rare case of Epitheliod Hemangioendothelioma in tongue. J Dent (Shiraz). 2019; 20: 70-74.
- Yendluri DB, Chinta C, Vedula C. Epithelioid Hemangioendothelioma of tongue: a rare presentation. J Dent (Shiraz). 2023; 24: 352-355.
- Bajpai M, Pardhe N, Kumar M. Non-infiltrating angiolipoma of palate. Cukurova Med J. 2018; 43: 471-474.