Association of Vitamin D Receptor Gene Polymorphisms with Periodontitis

Kami, Mohammad; Saghaeian Jazi, Marie; Allahyari, Mostafa; Fakhari, Elham

doi:10.30476/dentjods.2025.103866.2485

Association of Vitamin D Receptor Gene Polymorphisms with Periodontitis

Document Type : Original Article

Authors

Mohammad Kami ¹

Marie Saghaeian Jazi ²

Mostafa Allahyari ²

Elham Fakhari ¹

¹ Dental Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

² Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

https://doi.org/10.30476/dentjods.2025.103866.2485

Abstract

Background: Considering the role of vitamin D in regulation of the bone metabolism and the immune system, some have suggested the effect of vitamin D receptor gene polymorphism in susceptibility to periodontitis.
Purpose: We aimed to determine the association between vitamin D receptor (VDR) gene polymorphisms Fok1, Apa1, Bsm1, and Taq1 and periodontitis.
Materials and Method: In this case-control study, 51 patients with stage Ⅲ periodontitis (case group) and 51 without (control group) were enrolled. Blood samples were taken to analyze the single nucleotide polymorphism (SNP) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) after DNA extraction. Finally, the data were analyzed using SPSS software version 17, SNPStats, using Chi-square and t-test.
Results: The allelic frequencies of SNP1 (TaqI) (p Value=0.089), SNP2 (ApaI) (p= 0.481), SNP3 (BsmI) (p= 0.566), and SNP4 (FokI) (p= 0.658) were not different between the groups. Genotype frequencies in the four hereditary models of codominant, dominant, recessive and, overdominant were not different in any SNPs. Of 12 haplotypes identified in the study population, TCbF was most frequent in the case group and tABF in the control group (p> 0.05).
Conclusion: No significant association was found between VDR gene polymorphisms and periodontitis.

Keywords

Polymorphism

Periodontitis

Vitamin D receptor

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