Document Type : Review Article
Authors
1 Dental Student, Membership of Dental Material Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
2 Membership of Dental Material Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Abstract
Herbal medicine has been traditionally used in managing various health conditions, including oral diseases. With growing interest in natural treatments, numerous plant-derived compounds have been studied for their antimicrobial, anti-inflammatory, analgesic, and wound-healing properties. The present study aims to evaluate the influence of various types of herbal medicine in the management of oral conditions, along with their advantages and disadvantages. For this review article, a complete query was carried out on PubMed, Google Scholar, Embase, and Scopus databases, and the studies published during 2015-2024 were collected using the keywords such as "Herbal Medicine," "Oral Disorder," "Complementary Therapies", "Treatment Outcome," and "Drug Effects." After applying appropriate inclusion and exclusion criteria, 64 relevant articles focused on the application of herbal medicine in the treatment of oral diseases were selected and evaluated. Among all the medical herbs, aloe vera, turmeric, ginger, and green tea have shown more promising antimicrobial and anti-inflammatory properties that contribute to oral health. In other words, studies suggest that the mentioned herbs may aid in reducing plaque formation, managing gingival inflammation, promoting wound healing, and controlling oral microbial infections better than other herbs. As evidenced by the obtained results, herbal medicine holds promise as a complementary or alternative approach in oral care due to its bioactive properties and potential therapeutic benefits. However, further clinical trials and scientific validation is necessary to ensure safety, efficacy, and standardization before herbal treatments can be fully integrated into modern practice.
Keywords
- Amanpour S, Akbari Javar M, Sarhadinejad Z, Doustmohammadi M, Moghadari M, Sarhadynejad Z. A systematic review of medicinal plants and herbal products' effectiveness in oral health and dental cure with health promotion approach. J Educ Health Promot. 2023; 12: 306.
- Moghadam ET, Yazdanian M, Tahmasebi E, Tebyanian H, Ranjbar R, Yazdanian A, et al. Current herbal medicine as an alternative treatment in dentistry: In vitro, in vivo and clinical studies. Eur J Pharmacol. 2020; 889: 173665.
- Urban-Chmiel R, Marek A, Stępień-Pyśniak D, Wiecz-orek K, Dec M, Nowaczek A, et al. Antibiotic resistance in bacteria: A review. Antibiotics. 2022; 11: 1079.
- Budala DG, Martu MA, Maftei GA, Diaconu-Popa DA, Danila V, Luchian I. The Role of Natural Compounds in Optimizing Contemporary Dental Treatment-Current Status and Future Trends. J Funct Biomater. 2023; 14: 273.
- Yadav P, Tandon S, Khurana C, Chopra M. Herbs in dentistry. J Global Oral Health. 2024; 7: 46-60.
- Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Available at: https://www.bmj.com/cont-ent/bmj/372/bmj.n71.full.pdf
- Huang YC, Sung MY, Lin TK, Kuo CY, Hsu YC. Chinese herbal medicine compound of flavonoids adjunctive treatment for oral cancer. J Formos Med Assoc. 2024; 123: 830-836.
- Mobeen S, Sv R, Jd S, Prakash R, DS, Swayampakula H, et al. A Novel Herbal Paste Formulation of Turmeric, Tulsi, and Honey for the Treatment of Oral Submucous Fibrosis. Cureus. 2023; 15: e46608.
- Tan HL, Smith JG, Hoffmann J, Renton T. A systematic review of treatment for patients with burning mouth syndrome. Cephalalgia. 2022; 42: 128-1261.
- Rodrigues CF, Rodrigues ME, Henriques MCR. Promising Alternative Therapeutics for Oral Candidiasis. Curr Med Chem. 2019; 26: 2515-2528.
- Polansky H, Javaherian A, Itzkovitz E. Clinical trial of herbal treatment geneeden-VIR/novirin in oral herpes. J Evid Based Integr Med. 2018; 23: 2515690x18806-269.
- Li CL, Huang HL, Wang WC, Hua H. Efficacy and safety of topical herbal medicine treatment on recurrent aphthous stomatitis: a systemic review. Drug Des Devel Ther. 2016; 10: 107-115.
- Lugo-Flores MA, Quintero-Cabello KP, Palafox-Rivera P, Silva-Espinoza BA, Cruz-Valenzuela MR, Ortega-Ra-mirez LA, et al. Plant-Derived Substances with Antibacterial, Antioxidant, and Flavoring Potential to Formulate Oral Health Care Products. Biomedicines. 2021; 9: 1669.
- Dehghani*Nazhvani A, Sarafraz N, Askari F, Heidari F, Razmkhah M. Anti-Cancer Effects of Traditional Medicinal Herbs on Oral Squamous Cell Carcinoma. Asian Pac J Cancer Prev. 2020; 21: 479-84.
- Levi LE, Lalla RV. Dental Treatment Planning for the Patient with Oral Cancer. Dent Clin North Am. 2018; 62: 121-30.
- Ben-Arie E, Lottering B, Inprasit C, Yip HT, Ho WC, Ton G, et al. Traditional Chinese medicine use in patients with oral cancer: A retrospective longitudinal cohort study in Taiwan. Medicine (Baltimore). 2022; 101: e30716.
- Panjwani S, Rai S, Misra D, Misra A. Herbinaturals: A new paradigm in dentistry. J Indian Academy Oral Med Radi. 2016; 28: 150.
- Hu S, Li S, Xu Y, Huang X, Mai Z, Chen Y, et al. The antitumor effects of herbal medicine Triphala on oral cancer by inactivating PI3K/Akt signaling pathway: based on the network pharmacology, molecular docking, in vitro and in vivo experimental validation. Phytomedicine. 2024; 128: 155488.
- Kumar R, Mirza MA, Naseef PP, Kuruniyan MS, Zakir F, Aggarwal G. Exploring the Potential of Natural Product-Based Nanomedicine for Maintaining Oral Health. Molecules. 2022; 27: 1725.
- Dioguardi M, Ballini A, Sovereto D, Spirito F, Cazzolla AP, Aiuto R, et al. Application of the Extracts of Punica granatum in Oral Cancer: Scoping Review. Dent J (Basel). 2022; 10: 234.
- Peng SY, Hsiao CC, Lan TH, Yen CY, Farooqi AA, Cheng CM, et al. Pomegranate extract inhibits migration and invasion of oral cancer cells by downregulating matrix metalloproteinase-2/9 and epithelial-mesenchymal transition. Environ. Toxicol. 2020; 35: 673–682.
- Gao W, Wang J, Zhao J. Describing a modern chemotherapeutic drug prepared by Au nanoparticles to treat the human oral squamous cell carcinoma: A pre-clinical trial study. Inorg Chem Commun. 2022; 136: 109138.
- Rajesh*Kashyap R, Shanker*Kashyap R. Herbal derivatives in the management of mouth opening in oral sub mucous fibrosis-A network meta-analysis. Oral Dis. 2021; 27: 1606-1615.
- Shih YH, Wang TH, Shieh TM, Tseng YH. Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy. Int J Mol Sci. 2019; 20: 2940.
- Patil S, Sarode SC, Ashi H, Ali*Baeshen H, Thirumal Raj A, Awan KH, et al. Triphala extract negates arecoline-induced senescence in oral mucosal epithelial cells in vitro. Saudi J Biol Sci. 2021; 8: 2223-2228.
- Černáková L, Rodrigues CF. Microbial interactions and immunity response in oral Candida species. Future Microbiol. 2020; 15: 1653-1677.
- Gharibpour F, Shirban F, Bagherniya M, Nosouhian M, Sathyapalan T, Sahebkar A. The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review. Adv Exp Med Biol. 2021; 1308: 225-248.
- Mosaddad SA, Hussain A, Tebyaniyan H. Green alternatives as antimicrobial agents in mitigating periodontal diseases: A narrative review. Microorganisms. 2023; 11: 1269.
- Shafaroudi AM, Gorji NE, Nasiri P, Javidnia J, Saravi ME. Antifungal properties of zataria multiflora on candida species: A systematic review. J Evid Based Integr Med. 2022; 27: 2515690x221132272.
- Aghajani A, Abastabar M, Khalilian A, Haghani I, Jannati P, Ebrahimisaravi M. Comparing the antifungal effect of Sodium Hypochlorite, Deconex, Zataria multiflora, and Artemisia aucheri on the surface of acrylic resin dentures: An experimental study. J Maz Uni Med Sci. 2019; 29: 22-32.
- Zhang W, Zhang Y, Fan J, Feng Z, Song X. Pharmacological activity of capsaicin: Mechanisms and controversies (Review). Mol Med Rep. 2024; 29: 38.
- Behbehani JM, Irshad M, Shreaz S, Karched M. Anticandidal Activity of Capsaicin and Its Effect on Ergosterol Biosynthesis and Membrane Integrity of Candida albicans. Int J Mol Sci. 2023; 24: 1046.
- Eid*Abdelmagyd HA, Ram*Shetty DS, Musa*Musleh Al-Ahmari DM. Herbal medicine as adjunct in periodontal therapies- A review of clinical trials in past decade. J Oral Biol Craniofac Res. 2019; 9: 212-217.
- Khan SF, Shetty B, Fazal I, Khan AM, Mir FM, Moothedath M, et al. Licorice as a herbal extract in periodontal therapy. Drug Target Insights. 2023; 17: 70-77.
- AlDehlawi H, Jazzar A. The Power of Licorice (Radix glycyrrhizae) to Improve Oral Health: A Comprehensive Review of Its Pharmacological Properties and Clinical Implications. Healthcare (Basel). 2023; 11: 2887.
- Rajendiran M, Trivedi HM, Chen D, Gajendrareddy P, Chen L. Recent Development of Active Ingredients in Mouthwashes and Toothpastes for Periodontal Diseases. Molecules. 2021; 26: 2001.
- Shahare N, CHOUHAN S, Darwhekar GN. Herbs used in treatment of mouth ulcer- a review: Herbal medicines for treatment of mouth ulcer. Int J Pharm Chem. 2021; 2: 68-74.
- Bandana K, Kumar S, Sagar MK, Tyagi H. Formulation and evaluation of herbal gel of guava leaves and liquorice roots extract for using mouth ulcer. J Crit Rev. 2020; 7: 3097-3110.
- Sing R, Bansal S, Kumar Mishra M. Formulation and evaluation of herbal oral gel containing extracts of powdered Psidium guajava linn leaves with Curcuma longa linn rhizomes to treat mouth ulcer. Int J Drug Develop Res. 2020; 12: 1-7.
- Leiva-Cala C, Lorenzo-Pouso AI, Centenera-Centenera B, López-Palafox J, Gándara-Vila P, García-García A, et al. Clinical efficacy of an Aloe Vera gel versus a 0.12% c-hlorhexidine gel in preventing traumatic ulcers in patients with fixed orthodontic appliances: a double-blind randomized clinical trial. Odontology. 2020; 108: 470-478.
- Baharvand M, Jafari S, Mortazavi H. Herbs in Oral Mucositis. J Clin Diagn Res. 2017; 11: ZE05-ZE11.
- Ferreira AS, Macedo C, Silva AM, Delerue-Matos C, Costa P, Rodrigues F. Natural products for the prevention and treatment of oral Mucositis: A review. Int J Mol Sci. 2022; 23: 4385.
- Najafizade N, Mobini*Dehkordi R, Hemati S. Investigating the effect of Aloe vera on the prevention and treatment of radiotherapy-induced oral mucositis in patients with head-and-neck cancer. J Res Med Sci. 2024; 29: 16.
- De*Lima*Dantas JB, Freire TFC, Sanches ACB, Julião ELD, Medrado ARAP, Martins GB. Action of Matricariarecutita (chamomile) in the management of radiochemotherapy oral mucositis: A systematic review. Phytother Res. 2022; 36: 1115-1125.
- Shavakhi M, Sahebkar A, Shirban F, Bagherniya M. The efficacy of herbal medicine in the treatment of recurrent aphthous stomatitis: A systematic review of randomized clinical trials. Phytother Res. 2022; 36: 672-685.
- Ghahremanlo A, Boroumand N, Ghazvini K, Hashemy SI. Herbal medicine in oral lichen planus. Phytother Res. 2019; 33: 288-293.
- Pourshahidi S, Sheykhbahaei N. Effectiveness of herbal based medications in the treatment of oral lichen planus: a review article. J Herb Med. 2021; 1: 100458.
- Kalaskar AR, Bhowate RR, Kalaskar RR, Walde SR, Ramteke RD, Banode PP. Efficacy of Herbal Interventions in Oral Lichen Planus: A Systematic Review. Contemp Clin Dent. 2020; 11: 311-319.
- Thomas AE, Varma B, Kurup S, Jose R, Chandy ML, Kumar SP, et al. Evaluation of efficacy of 1% Curcuminoids as local application in management of oral lichen planus- interventional study. J Clin Diagn Res. 2017; 11: ZC89-ZC93.
- Vaidya A, Khorate M, Chinam N, Figueiredo N. Efficacy of Aloe Vera and Clobetasol Propionate in the Management of Oral Lichen Planus: A Randomized Parallel Clinical Trial. Front Dent. 2023; 20: 1-16.
- Rehman S, Iqbal Z, Qureshi R, AlOmar TS, Almasoud N, Younas M, et al. Ethno-Dentistry of Medicinal Plants Used in North Waziristan, Pakistan. Int Dent J. 2024; 74: 310-320.
- Khounganian RM, Alasmari ON, Aldosari MM. Causes and management of halitosis: A narrative review. Cureus. 2023; 15: e43742.
- Wu J, Cannon RD, Ji P, Farella M, Mei L. Halitosis: prevalence, risk factors, sources, measurement and treatment: a review of the literature. Aust Dent J. 2020; 65: 4-11.
- Resmisari R, Wicaksono S, Alfiani N, Effendi S. Siwak (Salvadora persica) extract as a natural anti-halitosis mouth spray. IOP Conf Se Earth Environ Sci. 2021; 733: 012131.
- Forouzanfar A, Mohammadipour HS, Forouzanfar F. The Potential Role of Tea in Periodontal Therapy: An Updated Review. Curr Drug Discov Technol. 2021; 18: 1-7.
- Henley-Smith CJ, Kok AM, Botha FS, Baker C, Lall N. The effect of a poly-herbal plant extract on the adhesion of Streptococcus mutans to tooth enamel. BMC Complement Med Ther. 2024; 24: 402.
- Pasupuleti MK, Nagate RR, Alqahtani SM, Penmetsa GS, Gottumukkala S, Ramesh KSV. Role of Medicinal Herbs in Periodontal Therapy: A Systematic Review. J Int Soc Prev Community Dent. 2023; 13: 9-16.
- Basu A, Masek E, Ebersole JL. Dietary Polyphenols and Periodontitis-A Mini-Review of Literature. Molecules. 2018; 23: 1786.
- Mhatre S, Srichand R, Sethumadhavan J, Mishra PB, Patil SD, Chavan RS, et al. Dry Mouth Dilemma: A Comprehensive Review of Xerostomia in Complete Denture Wearers. Cureus. 2024; 16: e58564.
- Sun Z, Deng L, Xu Z, Yang K, Yu P. Uncovering the molecular mechanism of Mume Fructus in treatment of Sjögren's syndrome. Medicine (Baltimore). 2024; 103: e38085.
- Wu F, Wu G, Li T, Lu W, Fu T, Zhang Z. Exploring the target and mechanism of radix paeoniae Alba on Sjogren's Syndrome. Comb Chem High Throughput Screen. 2023; 26: 1224-1232.
- Kontogiannopoulos KN, Kapourani A, Gkougkourelas I, Anagnostaki ME, Tsalikis L, Assimopoulou AN, et al. A Review of the Role of Natural Products as Treatment Approaches for Xerostomia. Pharmaceuticals (Basel). 2023; 16: 1136.
- Pärnänen P, Lomu S, Räisänen IT, Tervahartiala T, Sorsa T. Effects of Fermented Lingonberry Juice Mouthwash on Salivary Parameters-A One-Year Prospective Human Intervention Study. Dent J (Basel). 2022; 10: 69.
- Badooei F, Imani E, Hosseini-Teshnizi S, Banar M, Memarzade M. Comparison of the effect of ginger and aloe vera mouthwashes on xerostomia in patients with type 2 diabetes: A clinical trial, triple-blind. Med Oral Patol Oral Cir Bucal. 2021; 26: e408-e413.
- Dzobo K. The role of natural products as sources of therapeutic agents for innovative drug discovery. Comprehensive Pharmacology. 2022: 408-422.