Document Type : Case Report
Authors
1
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
2
School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
3
Hematology, Oncology &Stem Cell Transplantation Research Center, Research institution for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran.
4
Fellowship (Oral and Maxillofacial Oncology), Assistant Professor, Department of Oral and Maxillofacial Surgery, School of Dentistry, Islamic Azad University Tehran Medical Sciences, Tehran, Iran.
5
Dr. Yaghmaei Clinical Genetics Laboratory, Tehran, Iran.
10.30476/dentjods.2026.109295.2870
Abstract
Central odontogenic fibroma (COdF) is a rare benign tumor originating from odontogenic mesenchyme; a subset of cases exhibits hybrid features, particularly with central giant cell granuloma (CGCG). This study presents a rare case of epithelium-rich COdF associated with CGCG and a systematic review of this type of hybrid lesion. We report a 10-year-old male with a unilateral mandibular swelling and a progressively enlarging radiolucent lesion. Imaging and histopathological evaluation identified a benign mixed odontogenic tumor with epithelial-rich COdF features and multinucleated giant cells. Genetic testing for the SH3BP2 gene mutation, commonly associated with cherubism, was negative. Surgical resection and reconstruction were performed, with no recurrence observed at a 1-year follow-up. A review was conducted on hybrid COdF/CGCG lesions in PubMed, Embase, Scopus, Web of Science, and Wiley Online. Analyzing clinical, radiographic, and histopathological patterns, our findings highlight the necessity of molecular and histopathological differentiation for accurate diagnosis and treatment planning.
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