Document Type : Systematic Review
Authors
- Parinaz Kalejahi 1
- Katayoun Katebi 2
- Atefeh Abedi 3
- Fatemeh Salehnia 4
- Mohammad Amin Mehrali 3
- Neda Yasamineh 5
1 Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
3 Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Research Center for Evidence Based Medicine (RCEBM), Tabriz University of Medical Sciences, Tabriz, Iran
5 Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract
Background: Tissue engineering–based regenerative approaches are rapidly expanding in dentistry, particularly within endodontics, where dental mesenchymal stem cells play a pivotal role. Fat-soluble vitamins have been proposed as potential modulators of osteogenic and odontogenic differentiation.
Purpose: This systematic review aimed to evaluate the effects of fat-soluble vitamins on the osteogenic and odontogenic differentiation of dental mesenchymal stem cells.
Materials and Method: A comprehensive search was conducted in Web of Science, PubMed, Scopus, and Embase, using predefined keywords, from database inception to the last search date. Two independent reviewers screened titles, abstracts, and full texts according to the PRISMA guidelines. Additional studies were identified through manual searches of reference lists, relevant conference proceedings, and academic theses. Studies investigating the impact of fat-soluble vitamins on osteogenic and/or odontogenic differentiation of DMSCs were included.
Results: The search yielded 1,124 records, of which 13 studies met the inclusion criteria. Among the included studies, nine investigated the effects of vitamin D, two evaluated vitamin A, two assessed vitamin K, and one examined vitamin E. Overall, the included evidence suggests that fat-soluble vitamins can enhance osteogenic and odontogenic differentiation markers in various types of dental mesenchymal stem cells, although the extent and mechanisms varied across studies.
Conclusion: Fat-soluble vitamins demonstrate promising adjunctive effects in promoting osteogenic and odontogenic differentiation of dental mesenchymal stem cells. However, heterogeneity in study methodologies and outcomes highlights the need for standardized experimental designs and further mechanistic research to clarify their potential clinical applicability.
Keywords
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