Journal of Dentistry

Intra-Lesional Corticosteroid Therapy in Angioedema Secondary to Smokeless Tobacco: A Case-Based Evaluation of Therapeutic Efficacy

Articles in Press

Document Type : Case Reports

Authors

Jeya Saradha 1
Sangamesh N Chinnannavar 1
Silpiranjan Mishra 1
Jitendra Sharan 2

1 Dept. of Oral Medicine and Radiology, Kalinga Institute of Dental Sciences, Bhubaneswar, Odisha, India.

2 Dept. of Dentistry, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

10.30476/dentjods.2026.109909.2921
Abstract
The swelling that affects the face, lips, and tongue is known as angioedema. It is typically localized, asymmetrical, and mildly uncomfortable. The deep dermis and subcutaneous cellular tissue are affected by increased vascular permeability brought on by various bio-chemical mediators produced by mast cells (histamine, leukotrienes, prostaglandins), bradykinin, and complement products. This can cause swelling on the back of the hands, feet, and genitalia. Activation of the kallikrein-kinin cascade or mast cell degranulation can both result in angioedema. Acute urticaria or a more widespread anaphylactic reaction can also result from immunoglobulin E (IgE)-mediated hypersensitivity to foods or medications, which can also produce angioedema in the former scenario. This case report aims to present the clinical features and treatment of the angioedema in a 49-year-old male complaining of pain and swelling in the lower lip region.

Keywords

Angioedema
Tobacco
Smokeless/adverse effects
Drug Hypersensitivity
Triamcinolone Acetonide
Injections
Intralesional
Journal of Dentistry

Articles in Press, Accepted Manuscript
Available Online from 01 July 2026

  • Receive Date 30 November 2025
  • Revise Date 06 June 2026
  • Accept Date 01 July 2026
  • First Publish Date 01 July 2026
  • Publish Date 01 July 2026

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