Document Type : Original Article
Authors
1
a Department of Oral Medicine, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran b Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
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c Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
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d Pharmaceutical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran e Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences,
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f Dentist, Sari, Iran
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g Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
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h Department of Anesthesiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
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i Department of Oral and Maxillofacial Pathology, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran
10.30476/dentjods.2026.109134.2863
Abstract
Background: Oral aphthous lesion is the most prevalent ulcerative condition of oral mucosa.
Purpose: Due to lack of a specific treatment, our study aims to investigate the effectiveness of garlic oral tablets in managing aphthous lesions.
Materials and Method: In this unblinded randomized clinical trial study, 60 patients divided in two groups were enrolled in the study based on the inclusion criteria, receiving oral garlic tablets (n=30), and placebo (n=30). Patients took garlic or placebo tablets (containing 1.1 mg of allicin) four times per day. Patients reported their pain intensity using a visual numerical scale during follow-up sessions. Lesion diameter was measured by the examiner. Independent t-tests, Mann-Whitney, and chi-square tests were used for data analysis. Analysis was performed using SPSS 22 software, and the signifi-cance level was considered less than 0.05.
Results: The mean pain intensity on the third day was greater in the control group (P=0.045), and no significant difference was observed between the two groups, on other days. The mean lesion diameter was significantly different on days 3 and 5 which was greater in the control group (P=0.033 and P=0.046, respectively).
Conclusion: It seems that the administration of garlic tablets, each containing 1.1 mg of allicin, may reduce the pain intensity and the lesion diameter of aphthous lesions.
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