Document Type: Original Articles

Authors

1 Oral and Maxillofacial Diseases Research Center, Dept. of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of MedicalSciences, Mashhad, Iran.

3 Undergraduate Student, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Undergraduate Student, Faculty of Dentistry, Mashhad University of MedicalSciences, Mashhad, Iran.

Abstract

Statement of the Problems: Lichen planus is a chronic inflammatory disease. Free radicals and reactive oxygen species play important roles in pathogenesis of oral lichen planus (OLP). Isoprostanes show oxidative stress and are formed by free-radical mediated lipid peroxidation of arachidonic acid and cell membrane phospholipids.Purpose: This study was conducted to evaluate the plasma level of 8-isoprostane in patients suffering from erosive and non-erosive forms of OLP.Materials and Method: In this case-control study, 31 patients with OLP and 30 control subjects were enrolled. Plasma samples were obtained and the level of 8-isoprostane was measured with Sandwich enzyme-linked immunosorbent assay (ELISA) in both groups. The data were analyzed by using two-sample t-test, chi-square and ANOVA tests.Results: The results showed significant increase in the plasma level of 8-isoprostane in OLP group compared with the control group. The results of independent t-test revealed no significant correlation between the plasma level of isoprostane and sex, smoking, or previous treatment.Conclusion: Based on the findings of this study, oxidative stress was increased in patients with OLP, reflected by higher concentrations of 8-isoprostane in plasma.Key Words: Oral Lichen Planus; Isoprostane; Oxidative Stress